Advances in Regenerative Medicine and Tissue Engineering: Innovation and Transformation of Medicine.
Advances in Regenerative Medicine and Tissue Engineering: Innovation and Transformation of Medicine.
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DOI：
10.1155/2018/2495848
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发表时间：
2018
影响因子：
4.3
通讯作者：
Motaung KSCM
中科院分区：
文献类型：
--
作者：
Dzobo K;Thomford NE;Senthebane DA;Shipanga H;Rowe A;Dandara C;Pillay M;Motaung KSCM
人类和动物由于先天性缺陷、创伤和疾病而失去组织和器官。与通常被称为蝾螈的有尾目两栖动物相比，人体的再生潜力很低。在全球范围内，如果组织和器官可以按需更换，数百万人将受益匪浅。传统上，完整组织和器官的移植一直是替换身体受损和患病部位的基础。仅仅依靠移植造成了一个需要捐赠组织和器官的人的等待名单，而且一般来说，供应不能满足需求。在照顾器官衰竭和衰弱性疾病患者方面，社会的总成本是巨大的。出于开发安全可靠的组织和器官来源的需要，科学家和临床医生一直在改进可以再生组织的疗法和技术，在某些情况下甚至可以创造新的组织。组织工程和/或再生医学是生命科学的领域，采用工程和生物学原理来创建新的组织和器官，并促进受损或患病组织和器官的再生。组织工程和再生医学领域正在取得重大进展和创新，并对组织和器官的三维生物打印（3D生物打印）产生巨大影响。3D生物打印为人工组织和器官生物打印带来了巨大的希望，从而彻底改变了再生医学领域。本文讨论了再生医学和组织工程领域的最新进展如何改善3D生物打印，反之亦然。在3D生物打印的应用中，必须克服几个挑战，然后才能将这种颠覆性技术广泛用于创建再生医学的器官型构建体。
Humans and animals lose tissues and organs due to congenital defects, trauma, and diseases. The human body has a low regenerative potential as opposed to the urodele amphibians commonly referred to as salamanders. Globally, millions of people would benefit immensely if tissues and organs can be replaced on demand. Traditionally, transplantation of intact tissues and organs has been the bedrock to replace damaged and diseased parts of the body. The sole reliance on transplantation has created a waiting list of people requiring donated tissues and organs, and generally, supply cannot meet the demand. The total cost to society in terms of caring for patients with failing organs and debilitating diseases is enormous. Scientists and clinicians, motivated by the need to develop safe and reliable sources of tissues and organs, have been improving therapies and technologies that can regenerate tissues and in some cases create new tissues altogether. Tissue engineering and/or regenerative medicine are fields of life science employing both engineering and biological principles to create new tissues and organs and to promote the regeneration of damaged or diseased tissues and organs. Major advances and innovations are being made in the fields of tissue engineering and regenerative medicine and have a huge impact on three-dimensional bioprinting (3D bioprinting) of tissues and organs. 3D bioprinting holds great promise for artificial tissue and organ bioprinting, thereby revolutionizing the field of regenerative medicine. This review discusses how recent advances in the field of regenerative medicine and tissue engineering can improve 3D bioprinting and vice versa. Several challenges must be overcome in the application of 3D bioprinting before this disruptive technology is widely used to create organotypic constructs for regenerative medicine.
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影响因子：
--
作者：
Fu XM;Lee JK;Miwa K;Shimizu T;Takagishi Y;Hirabayashi M;Watabe K;Usui A;Kodama I;Ueda Y
通讯作者：
Ueda Y
影响因子：
--
作者：
Abakuks, S.;Deters, A. M.
通讯作者：
Deters, A. M.
影响因子：
3
作者：
Arkudas, Andreas;Beier, Justus Patrick;Kneser, Ulrich
通讯作者：
Kneser, Ulrich
影响因子：
6.2
作者：
ALMOND, PS;MATAS, AJ;NAJARIAN, JS
通讯作者：
NAJARIAN, JS
影响因子：
14
作者：
Aamodt JM;Grainger DW
通讯作者：
Grainger DW