Gout: An old disease in new perspective - A review.
Gout: An old disease in new perspective - A review.
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DOI：
10.1016/j.jare.2017.04.008
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发表时间：
2017-09
影响因子：
10.7
通讯作者：
Bardin T
中科院分区：
文献类型：
--
作者：
Ragab G;Elshahaly M;Bardin T
痛风是一种常见的尿酸紊乱。这是最好的理解和描述类型的关节炎。对其流行病学进行了研究。高尿酸血症和痛风性关节炎的病理生理学的新见解;急性和慢性允许更好地了解疾病。遗传易感性的作用越来越明显。痛风的临床表现分为无症状高尿酸血症、急性痛风性关节炎、临界期和慢性痛风石性痛风。诊断基于实验室和放射学特征。诊断的金标准是使用偏振光显微镜鉴定滑液中的特征性MSU晶体。成像方式包括常规X线摄影、超声检查、常规CT、双能CT、磁共振成像、核素扫描和正电子发射断层扫描。超声和双能CT的应用取得了显著的进展，这必将影响该领域的诊断、分期、随访和临床研究。痛风的管理包括管理突发、慢性痛风和预防突发，以及管理合并症。药理学医疗设备中的新药物正在证明是成功的，并补充了旧药物。其管理的其他要点包括患者教育，饮食和生活方式的改变，以及停止高尿酸血症药物。
Gout is a picturesque presentation of uric acid disturbance. It is the most well understood and described type of arthritis. Its epidemiology is studied. New insights into the pathophysiology of hyperuricemia and gouty arthritis; acute and chronic allow for an even better understanding of the disease. The role of genetic predisposition is becoming more evident. The clinical picture of gout is divided into asymptomatic hyperuricemia, acute gouty arthritis, intercritical period, and chronic tophaceous gout. Diagnosis is based on laboratory and radiological features. The gold standard of diagnosis is identification of characteristic MSU crystals in the synovial fluid using polarized light microscopy. Imaging modalities include conventional radiography, ultrasonography, conventional CT, Dual-Energy CT, Magnetic Resonance Imaging, nuclear scintigraphy, and positron emission tomography. There is remarkable progress in the application of ultrasonography and Dual-Energy CT which is bound to influence the diagnosis, staging, follow-up, and clinical research in the field. Management of gout includes management of flares, chronic gout and prevention of flares, as well as management of comorbidities. Newer drugs in the pharmacological armamentarium are proving successful and supplement older ones. Other important points in its management include patient education, diet and life style changes, as well as cessation of hyperuricemic drugs.
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影响因子：
2.9
作者：
Bobulescu IA;Moe OW
通讯作者：
Moe OW
双能CT诊断痛风的CT：精确性和诊断产量研究。
影响因子：
27.4
作者：
Bongartz T;Glazebrook KN;Kavros SJ;Murthy NS;Merry SP;Franz WB 3rd;Michet CJ;Veetil BM;Davis JM 3rd;Mason TG 2nd;Warrington KJ;Ytterberg SR;Matteson EL;Crowson CS;Leng S;McCollough CH
通讯作者：
McCollough CH
影响因子：
2.1
作者：
Chen, CH;Chen, CKH;Yang, CF
通讯作者：
Yang, CF
影响因子：
16.2
作者：
Azadbakht, L;Mirmiran, P;Azizi, F
通讯作者：
Azizi, F
影响因子：
1.2
作者：
Ahmad, I.;Tejada, J. G.
通讯作者：
Tejada, J. G.