An Introduction to Forensic Genetics
An Introduction to Forensic Genetics
复制标题
法医遗传学简介
DOI：
--
复制
发表时间：
2007
期刊：
影响因子：
--
通讯作者：
W. Goodwin
中科院分区：
文献类型：
--
作者：
S. Hadi;A. Linacre;W. Goodwin
内容。前言。1法医遗传学导论。法医遗传学。法医遗传学简史。参考文献2 DNA结构与基因组。DNA结构。将DNA组织成染色体。人类基因组的结构。现代人类的基因多样性。基因组和法医遗传学。串联重复序列。单核苷酸多态性。进一步阅读。参考文献3 .生物材料-收集、表征和储存。生物证据的来源。在犯罪现场收集和处理材料。鉴定和鉴定生物证据。收集证据。性侵犯和身体侵犯。假定测试。生物材料的储存。参考文献4 DNA的提取和定量。DNA提取。从具有挑战性的样本中提取DNA。DNA的定量。DNA IQTM系统。参考文献5 .聚合酶链反应。法医遗传学中基于pcr的分析方法的发展。DNA复制——聚合酶链反应的基础。PCR的组成部分。PCR过程。PCR抑制。敏感性和污染。PCR实验室。进一步阅读。参考文献6短串联重复序列的分析。STR基因座结构。STR多路复用的发展。STR多态性检测。解释STR配置文件。进一步阅读。参考文献7 . STR概况的评估。口吃的峰值。分裂峰（+/- A）。引体向上。模板DNA。重载的概要文件。低拷贝数DNA。峰的平衡。混合物。退化的DNA。参考文献8 . STR资料的统计解释。群体遗传学。偏离Hardy-Weinberg平衡。确定偏离Hardy-Weinberg平衡的统计检验。估计STR谱线的频率。对等位基因频率数据库的修正。应该使用哪个人口频率数据库？结论。进一步阅读。参考文献。9 DNA证据的评估和呈现。命题的层次。似然比率。两个谬论。三种方法的比较。进一步阅读。参考文献。10 DNA档案数据库。英国国家DNA数据库。国际形势。有用的网站。参考文献。11亲属关系检验。亲子鉴定测试。鉴定人类遗骸。进一步阅读。参考文献12单核苷酸多态性。snp -发生和结构。snp检测。SNP检测的法医应用。snp的法医学应用。snp与STR位点的比较。进一步阅读。参考文献：13个血统标记。线粒体。mtDNA分析的应用。Y染色体。Y染色体多态性的法医学应用。进一步阅读。有用的网站。附录1取证参数。附录2有用的网页链接。术语表。缩写词。索引。
Contents. Preface. 1 Introduction to forensic genetics. Forensic genetics. A brief history of forensic genetics. References. 2 DNA structure and the genome. DNA structure. Organization of DNA into chromosomes. The structure of the human genome. Genetic diversity of modern humans. The genome and forensic genetics. Tandem repeats. Single nucleotide polymorphisms. Further reading. References. 3 Biological material - collection, characterization and storage. Sources of biological evidence. Collection and handling of material at the crime scene. Identification and characterization of biological evidence. Evidence collection. Sexual and physical assault. Presumptive testing. Storage of biological material. References. 4 DNA extraction and quantification. DNA extraction. DNA extraction from challenging samples. Quantification of DNA. DNA IQTM system. References. 5-The polymerase chain reaction. The evolution of PCR-based profiling in forensic genetics. DNA replication - the basis of the PCR. The components of PCR. The PCR process. PCR inhibition. Sensitivity and contamination. The PCR laboratory. Further reading. References. 6 The analysis of short tandem repeats. Structure of STR loci. The development of STR multiplexes. Detection of STR polymorphisms. Interpretation of STR profiles. Further reading. References. 7-Assessment of STR profiles. Stutter peaks. Split peaks (+/- A). Pull-up. Template DNA. Overloaded profiles. Low copy number DNA. Peak balance. Mixtures. Degraded DNA. References. 8 Statistical interpretation of STR profiles. Population genetics. Deviation from the Hardy-Weinberg equilibrium. Statistical tests to determine deviation from the Hardy-Weinberg equilibrium. Estimating the frequencies of STR profiles. Corrections to allele frequency databases. Which population frequency database should be used? Conclusions. Further reading. References. 9 The evaluation and presentation of DNA evidence. Hierarchies of propositions. Likelihood ratios. Two fallacies. Comparison of three approaches. Further reading. References. 10 Databases of DNA profiles. The UK national DNA Database. International situation. Useful web sites. References. 11 Kinship testing. Paternity testing. Identification of human remains. Further reading. References. 12 Single nucleotide polymorphisms. SNPs - occurrence and structure. Detection of SNPs. SNP detection for forensic applications. Forensic applications of SNPs. SNPs compared to STR loci. Further reading. References. 13 Lineage markers. Mitochondria. Applications of mtDNA profiling. The Y chromosome. Forensic applications of Y chromosome polymorphisms. Further reading. Useful web sites. Appendix 1 Forensic parameters. Appendix 2 Useful web links. Glossary. Abbreviations. Index.
登录
查看更多内容
应用自动 DNA 大小测定技术对微卫星位点进行基因分型。
影响因子：
4.4
作者：
Ziegle,JS;Su,Y;Corcoran,KP;Nie,L;Mayrand,PE;Hoff,LB;McBride,LJ;Kronick,MN;Diehl,SR
通讯作者：
Diehl,SR
DOI：
10.1073/pnas.0503809102
发表时间：
2005-07-19
影响因子：
11.1
作者：
Riehn, R;Lu, MC;Austin, RH
通讯作者：
Austin, RH
DOI：
10.1073/pnas.77.11.6715
发表时间：
1980-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
GILES, RE;BLANC, H;WALLACE, DC
通讯作者：
WALLACE, DC
影响因子：
4.4
作者：
Miller, RD;Phillips, MS;Kwok, PY
通讯作者：
Kwok, PY
影响因子：
1.9
作者：
GUO, SW;THOMPSON, EA
通讯作者：
THOMPSON, EA