Confocal comparison of corneal reinnervation after small incision lenticule extraction (SMILE) and femtosecond laser in situ keratomileusis (FS-LASIK).
Confocal comparison of corneal reinnervation after small incision lenticule extraction (SMILE) and femtosecond laser in situ keratomileusis (FS-LASIK).
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小切口晶状体摘除术 (SMILE) 和飞秒激光原位角膜磨镶术 (FS-LASIK) 后角膜神经支配的共焦比较。
DOI：
10.1371/journal.pone.0081435
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Zhou X
中科院分区：
文献类型：
--
作者：
Li M;Niu L;Qin B;Zhou Z;Ni K;Le Q;Xiang J;Wei A;Ma W;Zhou X
目的评价小切口晶状体摘除术（SMILE）和飞秒激光原位角膜磨角膜移植术（FS-LASIK）术后角膜再神经的恢复情况，以及相应的角膜敏感性和角膜细胞密度。在这项前瞻性、非随机观察性研究中，18例（32眼）患者接受SMILE手术，22例（42眼）患者接受FS-LASIK手术矫正近视。术前、术后1周、1个月、3个月和6个月用共聚焦显微镜观察角膜基底下神经密度和角膜结构的显微形态学变化。对角膜基底下神经密度与相应的角质细胞密度和角膜敏感性进行相关性分析。在1周（P = 0.0147）、1个月（P = 0.0243）和3个月（P = 0.0498）时，smile治疗组的基底下神经密度下降程度低于fs - lasik治疗组，但在6个月的随访中没有发现差异（P = 0.5277）。两组基底下神经密度与角膜中央敏感度呈正相关（r = 0.416， P<0.0001； SMILE组和FS-LASIK组分别r = 0.2567, P = 0.0038）。接受smile治疗的眼睛周围出现上皮细胞填充的空腔的风险较低（P = 0.0005）。在手术后的前3个月，SMILE组的基底下神经纤维密度下降比FS-LASIK组轻。基底下神经密度与角膜中央敏感度相关。
To evaluate corneal reinnervation, and the corresponding corneal sensitivity and keratocyte density after small incision lenticule extraction (SMILE) and femtosecond laser in situ keratomileusis (FS-LASIK). In this prospective, non-randomized observational study, 18 patients (32 eyes) received SMILE surgery, and 22 patients (42 eyes) received FS-LASIK surgery to correct myopia. The corneal subbasal nerve density and microscopic morphological changes in corneal architecture were evaluated by confocal microscopy prior to surgery and at 1 week, 1 month, 3 months, and 6 months after surgery. A correlation analysis was performed between subbasal corneal nerve density and the corresponding keratocyte density and corneal sensitivity. The decrease in subbasal nerve density was less severe in SMILE-treated eyes than in FS-LASIK-treated eyes at 1 week (P = 0.0147), 1 month (P = 0.0243), and 3 months (P = 0.0498), but no difference was detected at the 6-month visit (P = 0.5277). The subbasal nerve density correlated positively with central corneal sensitivity in both groups (r = 0.416, P<0.0001, and r = 0.2567, P = 0.0038 for SMILE group and FS-LASIK group, respectively). The SMILE-treated eyes have a lower risk of developing peripheral empty space with epithelial cells filling in (P = 0.0005). The decrease in subbasal nerve fiber density was less severe in the SMILE group than the FS-LASIK group in the first 3 months following the surgeries. The subbasal nerve density was correlated with central corneal sensitivity.
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影响因子：
4.2
作者：
Lee, Seung Jae;Kim, Jin Kuk;Lee, Hyung Keun
通讯作者：
Lee, Hyung Keun
影响因子：
3.4
作者：
Vestergaard, Anders;Ivarsen, Anders;Hjortdal, Jesper O.
通讯作者：
Hjortdal, Jesper O.
影响因子：
4.2
作者：
Erie, JC;McLaren, JW;Bourne, WM
通讯作者：
Bourne, WM
影响因子：
2.8
作者：
Salomao, Marcella Q.;Ambrosio, Renato, Jr.;Wilson, Steven E.
通讯作者：
Wilson, Steven E.
影响因子：
13.7
作者：
Erie, JC;Nau, CB;Bourne, WM
通讯作者：
Bourne, WM