Developing an international Pseudomonas aeruginosa reference panel.
Developing an international Pseudomonas aeruginosa reference panel.
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DOI：
10.1002/mbo3.141
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发表时间：
2013-12
期刊：
影响因子：
3.4
通讯作者：
Winstanley, Craig
中科院分区：
文献类型：
--
作者：
De Soyza, Anthony;Hall, Amanda J.;Mahenthiralingam, Eshwar;Drevinek, Pavel;Kaca, Wieslaw;Drulis-Kawa, Zuzanna;Stoitsova, Stoyanka R.;Toth, Veronika;Coenye, Tom;Zlosnik, James E. A.;Burns, Jane L.;Sa-Correia, Isabel;De Vos, Daniel;Pirnay, Jean-Paul;Kidd, Timothy J.;Reid, David;Manos, Jim;Klockgether, Jens;Wiehlmann, Lutz;Tuemmler, Burkhard;McClean, Siobhan;Winstanley, Craig
铜绿假单胞菌是囊性纤维化患者的主要机会致病菌，在其他易感人群中可引起广泛的感染。它对许多抗菌素的固有耐药性也使治疗这种病原体的感染变得困难。最近的证据强调了该物种的多样性，尽管如此，大多数关于毒力和致病机理的研究都集中在少数菌株上。迫切需要一个铜绿假单胞菌参考小组，以协调和协调铜绿假单胞菌研究界的集体努力。我们已经整理了一组43个铜绿假单胞菌菌株，这些菌株反映了生物体的多样性。除了通常研究的克隆外，该小组还包括可传播的菌株、连续的CF分离株、具有特定毒力特征的菌株以及代表血清型、基因型或地理多样性的菌株。这一集中的铜绿假单胞菌分离株小组将有助于加速和巩固毒力决定因素的发现，提高我们对这种病原体引起的感染的发病机制的了解，并为社区测试新的治疗药物提供宝贵的资源。
Pseudomonas aeruginosa is a major opportunistic pathogen in cystic fibrosis (CF) patients and causes a wide range of infections among other susceptible populations. Its inherent resistance to many antimicrobials also makes it difficult to treat infections with this pathogen. Recent evidence has highlighted the diversity of this species, yet despite this, the majority of studies on virulence and pathogenesis focus on a small number of strains. There is a pressing need for a P. aeruginosa reference panel to harmonize and coordinate the collective efforts of the P. aeruginosa research community. We have collated a panel of 43 P. aeruginosa strains that reflects the organism's diversity. In addition to the commonly studied clones, this panel includes transmissible strains, sequential CF isolates, strains with specific virulence characteristics, and strains that represent serotype, genotype or geographic diversity. This focussed panel of P. aeruginosa isolates will help accelerate and consolidate the discovery of virulence determinants, improve our understanding of the pathogenesis of infections caused by this pathogen, and provide the community with a valuable resource for the testing of novel therapeutic agents.
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影响因子：
3.7
作者：
Cigana C;Curcurù L;Leone MR;Ieranò T;Lorè NI;Bianconi I;Silipo A;Cozzolino F;Lanzetta R;Molinaro A;Bernardini ML;Bragonzi A
通讯作者：
Bragonzi A
影响因子：
10
作者：
Al-Aloul, M;Crawley, J;Walshaw, MJ
通讯作者：
Walshaw, MJ
影响因子：
6.4
作者：
Carter, Melissa E. K.;Fothergill, Joanne L.;Winstanley, Craig
通讯作者：
Winstanley, Craig
影响因子：
6.4
作者：
Ernst, Robert K.;Moskowitz, Samuel M.;Miller, Samuel I.
通讯作者：
Miller, Samuel I.
影响因子：
3.2
作者：
Feil, EJ;Li, BC;Spratt, BG
通讯作者：
Spratt, BG