Magneto-aerotactic bacteria deliver drug-containing nanoliposomes to tumour hypoxic regions.
Magneto-aerotactic bacteria deliver drug-containing nanoliposomes to tumour hypoxic regions.
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DOI：
10.1038/nnano.2016.137
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发表时间：
2016-11
影响因子：
38.3
通讯作者：
Martel S
中科院分区：
文献类型：
--
作者：
Felfoul O;Mohammadi M;Taherkhani S;de Lanauze D;Zhong Xu Y;Loghin D;Essa S;Jancik S;Houle D;Lafleur M;Gaboury L;Tabrizian M;Kaou N;Atkin M;Vuong T;Batist G;Beauchemin N;Radzioch D;Martel S
肿瘤中氧耗尽的缺氧区域通常对治疗有抗性。尽管纳米载体已被用于递送药物，但靶向比率非常低。在这里，我们表明，趋磁细菌，海洋磁球菌菌株MC-1的磁-趋氧迁移行为，可用于运输载药纳米脂质体到肿瘤的缺氧区域。在它们的自然环境中，MC-1细胞，每一个都包含一个磁性氧化铁纳米晶体链，倾向于沿着局部磁场线游泳，并基于双态趋氧传感系统向低氧浓度游去。我们发现，当将带有共价结合的含药物纳米脂质体的MC-1细胞注射到SCID Beige小鼠的肿瘤附近并进行磁性引导时，高达55%的MC-1细胞渗透到HCT 116结直肠异种移植物的缺氧区域。将约70个载药纳米脂质体附着于每个MC-1细胞。我们的研究结果表明，利用成群的微生物表现出磁趋氧行为可以显着提高各种纳米载体在肿瘤缺氧区域的治疗指数。
Oxygen depleted hypoxic regions in the tumour are generally resistant to therapies. Although nanocarriers have been used to deliver drugs, the targeting ratios have been very low. Here, we show that the magneto-aerotactic migration behaviour of magnetotactic bacteria, Magnetococcus marinus strain MC-1, can be used to transport drug-loaded nanoliposomes into hypoxic regions of the tumour. In their natural environment, MC-1 cells, each containing a chain of magnetic iron-oxide nanocrystals, tend to swim along local magnetic field lines and towards low oxygen concentrations based on a two-state aerotactic sensing system. We show that when MC-1 cells bearing covalently bound drug-containing nanoliposomes were injected near the tumour in SCID Beige mice and magnetically guided, up to 55% of MC-1 cells penetrated into hypoxic regions of HCT116 colorectal xenografts. Approximately 70 drug-loaded nanoliposomes were attached to each MC-1 cell. Our results suggest that harnessing swarms of microorganisms exhibiting magneto-aerotactic behaviour can significantly improve the therapeutic index of various nanocarriers in tumour hypoxic regions.
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影响因子：
64.8
作者：
Dreyfus, R;Baudry, J;Bibette, J
通讯作者：
Bibette, J
影响因子：
3.4
作者：
Frankel, RB;Bazylinski, DA;Taylor, BL
通讯作者：
Taylor, BL
影响因子：
17.1
作者：
Taherkhani, Samira;Mohammadi, Mahmood;Tabrizian, Maryam
通讯作者：
Tabrizian, Maryam
转铁蛋白修饰的负载羟基喜树碱的聚乙二醇化脂质体的有效肿瘤靶向
影响因子：
10.8
作者：
Hong, Minghuang;Zhu, Saijie;Pei, Yuanying
通讯作者：
Pei, Yuanying
DOI：
10.1099/ijs.0.038927-0
发表时间：
2013-03-01
影响因子：
2.8
作者：
Bazylinski, Dennis A.;Williams, Timothy J.;Beveridge, Terrence J.
通讯作者：
Beveridge, Terrence J.