Electrical impedance myography for monitoring motor neuron loss in the SOD1 G93A amyotrophic lateral sclerosis rat.
Electrical impedance myography for monitoring motor neuron loss in the SOD1 G93A amyotrophic lateral sclerosis rat.
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DOI：
10.1016/j.clinph.2011.04.021
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发表时间：
2011-12
期刊：
影响因子：
--
通讯作者：
Rutkove SB
中科院分区：
文献类型：
--
作者：
Wang LL;Spieker AJ;Li J;Rutkove SB
人体研究表明，电阻抗肌电图（EIM），一种基于高频，低强度电流的局部肌肉区域的表面应用技术，是敏感的肌肉去神经。在这项研究中，我们研究了EIM作为一个潜在的生物标志物评估ALS疾病进展的SOD 1转基因大鼠的作用，通过比较它的运动单位数估计（MUNE）。从大约10周龄开始，在16只大鼠中每周两次进行多频率EIM和MUNE。四个不同的EIM措施进行了评估，包括先前研究的50 kHz相位和三个浓缩的多频参数。100-500 kHz的多频率相位数据的恶化率与生存率的相关性最强（ρ = 0.79，p < 0.001），超过了MUNE（ρ = 0.57，p = 0.020）。这两个测量值也彼此强相关（ρ =-0.94，p < 0.001）。这些发现支持EIM是评估ALS大鼠疾病进展的有效工具。鉴于其易于应用和评估几乎任何浅表肌肉的能力，它值得进一步研究作为人类ALS临床治疗试验的生物标志物。
Human studies have shown that electrical impedance myography (EIM), a technique based on the surface application of high-frequency, low-intensity electrical current to localized areas of muscle, is sensitive to muscle denervation. In this study, we examined the role of EIM as a potential biomarker for assessing ALS disease progression in the SOD1 transgenic rat by comparing it to motor unit number estimation (MUNE). Multi-frequency EIM and MUNE were performed twice weekly in 16 rats from approximately 10 weeks of age onward. Four different EIM measures were evaluated, including the previously studied 50 kHz phase and three condensed multi-frequency parameters. The rate of deterioration in the multi-frequency phase data from 100-500 kHz had the strongest correlation to survival (ρ = 0.79, p < 0.001), surpassing that of MUNE (ρ = 0.57, p = 0.020). These two measures were also strongly correlated (ρ = -0.94, p < 0.001) to one another. These findings support that EIM is an effective tool for assessing disease progression in the ALS rat. Given its ease of application and ability to assess virtually any superficial muscle, it deserves further study as a biomarker in human ALS clinical therapeutic trials.
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影响因子：
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作者：
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