Long-term exposure to fine particulate matter and hospitalization in COVID-19 patients.

Long-term exposure to fine particulate matter and hospitalization in COVID-19 patients.
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COVID-19患者长期暴露于细颗粒物和住院治疗。

DOI:
10.1016/j.rmed.2021.106313
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发表时间:
2021-03
影响因子:
4.3
通讯作者:
Pinney SM
Pinney SM
中科院分区:
医学3区
文献类型:
--
作者:
Mendy A;Wu X;Keller JL;Fassler CS;Apewokin S;Mersha TB;Xie C;Pinney SM

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生态证据表明,接触空气污染会影响 2019 年冠状病毒病 (COVID-19) 的结果。然而,迄今为止,还没有个人层面的研究证实这种关联。我们确定了在辛辛那提大学医院和诊所诊断的 COVID-19 患者,并估计了他们的住宅邮政编码在 10 年期间(2008 年至 2017 年)的颗粒物 ≤2.5 μm (PM2.5) 暴露情况。我们使用逻辑回归来评估 PM2.5 暴露与 COVID-19 住院之间的关联,并根据社会经济特征和合并症进行调整。在我们研究中纳入的 1128 名患者中,10 年平均暴露量的 PM2.5 平均值(标准差)为 11.34 (0.70) µg/m3,10 年最大暴露量为 13.83 (1.03) µg/m3。长期接触 PM2.5 与因 COVID-19 住院之间的关联取决于是否患有哮喘或慢性阻塞性肺病 (COPD)(平均 PM2.5 的 Pinteraction = 0.030,最大 PM2.5 的 Pinteraction = 0.001)。在患有哮喘或慢性阻塞性肺病的 COVID-19 患者中,10 年平均 PM2.5 增加 1 μg/m3 时,住院几率增加 62%(比值比 [OR]:1.62,95% 置信区间 [CI]:1.00–2.64),10 年最大 PM2.5 水平增加 1 μg/m3 时,住院几率增加 65%(OR: 1.65,95% CI:1.16–2.35)。然而,在没有哮喘或 COPD 的 COVID-19 患者中,PM2.5 暴露与较高的住院率无关(平均 PM2.5 的 OR:0.84,95% CI:0.65–1.09;最大 PM2.5 的 OR:0.78,95% CI:0.65–0.95)。长期暴露于 PM2.5 与患有哮喘或慢性阻塞性肺病 (COPD) 的 COVID-19 患者住院几率较高相关。
Ecological evidence suggests that exposure to air pollution affects coronavirus disease 2019 (COVID-19) outcomes. However, no individual-level study has confirmed the association to date. We identified COVID-19 patients diagnosed at the University of Cincinnati hospitals and clinics and estimated particulate matter ≤2.5 μm (PM2.5) exposure over a 10-year period (2008–2017) at their residential zip codes. We used logistic regression to evaluate the association between PM2.5 exposure and hospitalizations for COVID-19, adjusting for socioeconomic characteristics and comorbidities. Among the 1128 patients included in our study, the mean (standard deviation) PM2.5 was 11.34 (0.70) μg/m3 for the 10-year average exposure and 13.83 (1.03) μg/m3 for the 10-year maximal exposures. The association between long-term PM2.5 exposure and hospitalization for COVID-19 was contingent upon having pre-existing asthma or chronic obstructive pulmonary (COPD) (Pinteraction = 0.030 for average PM2.5 and Pinteraction = 0.001 for maximal PM2.5). In COVID-19 patients with asthma or COPD, the odds of hospitalization were 62% higher with 1 μg/m3 increment in 10-year average PM2.5 (odds ratio [OR]: 1.62, 95% confidence interval [CI]: 1.00–2.64) and 65% higher with 1 μg/m3 increase in 10-year maximal PM2.5 levels (OR: 1.65, 95% CI: 1.16–2.35). However, among COVID-19 patients without asthma or COPD, PM2.5 exposure was not associated with higher hospitalizations (OR: 0.84, 95% CI: 0.65–1.09 for average PM2.5 and OR: 0.78, 95% CI: 0.65–0.95 for maximal PM2.5). Long-term exposure to PM2.5 is associated with higher odds of hospitalization in COVID-19 patients with pre-existing asthma or COPD.
DOI: 10.1126/sciadv.abd4049
发表时间: 2020-11
期刊: Science advances
影响因子: 13.6
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期刊: Environmental health : a global access science source
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影响因子: 24.7
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