Recovery of Theta Frequency Oscillations in Rats Following Lateral Fluid Percussion Corresponds With a Mild Cognitive Phenotype.
Recovery of Theta Frequency Oscillations in Rats Following Lateral Fluid Percussion Corresponds With a Mild Cognitive Phenotype.
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侧液打击乐后大鼠中theta频率振荡的恢复与轻度认知表型相对应。
DOI：
10.3389/fneur.2020.600171
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发表时间：
2020
影响因子：
3.4
通讯作者：
Gurkoff GG
中科院分区：
文献类型：
--
作者：
Ondek K;Pevzner A;Tercovich K;Schedlbauer AM;Izadi A;Ekstrom AD;Cowen SL;Shahlaie K;Gurkoff GG
无论是跌倒，运动脑震荡，甚至是战斗损伤，都迫切需要确定一个人在创伤性脑损伤（TBI）后何时能够重返游戏或工作。脑电图（EEG）和局部场电位（LFP）是监测与学习和记忆相关的回路水平异常的潜在工具：具体来说，θ波振荡可以很容易地观察到，并在认知中发挥关键作用。在大鼠中度创伤性脑损伤后，θ波振荡的持续变化与空间学习的缺陷一致。因此，我们假设θ波振荡可以作为恢复的客观生物标志物，振荡活动的恢复与空间学习的改善相对应。本研究记录了损伤后第3天和第7天在新环境中清醒行为的成年Sprague Dawley大鼠背侧海马和前扣带的LFP，以及损伤后第8-11天的Barnes迷宫空间导航。通过功率、θ - δ比、θ峰频率和相位相干性测量的θ波振荡在第3天发生了显著变化，但在损伤后第7天基本恢复。根据逃避潜伏期的测量，受伤的大鼠表现出轻微的行为表型，与巴恩斯迷宫中的假体没有什么不同。受伤大鼠确实使用了次优搜索策略。结合我们之前的研究结果，证明了theta振荡的持续改变与空间学习缺陷之间的相关性，这些新数据表明，神经振荡，特别是theta振荡，有可能作为监测TBI后脑功能恢复的生物标志物。具体来说，我们现在证明了振荡在受伤后会被抑制，但随着振荡的恢复，行为也会随之恢复。
Whether from a fall, sports concussion, or even combat injury, there is a critical need to identify when an individual is able to return to play or work following traumatic brain injury (TBI). Electroencephalogram (EEG) and local field potentials (LFP) represent potential tools to monitor circuit-level abnormalities related to learning and memory: specifically, theta oscillations can be readily observed and play a critical role in cognition. Following moderate traumatic brain injury in the rat, lasting changes in theta oscillations coincide with deficits in spatial learning. We hypothesized, therefore, that theta oscillations can be used as an objective biomarker of recovery, with a return of oscillatory activity corresponding with improved spatial learning. In the current study, LFP were recorded from dorsal hippocampus and anterior cingulate in awake, behaving adult Sprague Dawley rats in both a novel environment on post-injury days 3 and 7, and Barnes maze spatial navigation on post-injury days 8–11. Theta oscillations, as measured by power, theta-delta ratio, peak theta frequency, and phase coherence, were significantly altered on day 3, but had largely recovered by day 7 post-injury. Injured rats had a mild behavioral phenotype and were not different from shams on the Barnes maze, as measured by escape latency. Injured rats did use suboptimal search strategies. Combined with our previous findings that demonstrated a correlation between persistent alterations in theta oscillations and spatial learning deficits, these new data suggest that neural oscillations, and particularly theta oscillations, have potential as a biomarker to monitor recovery of brain function following TBI. Specifically, we now demonstrate that oscillations are depressed following injury, but as oscillations recover, so does behavior.
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细胞外田地和电流的起源-EEG，ECOG，LFP和尖峰。
DOI：
10.1038/nrn3241
发表时间：
2012-05-18
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Buzsáki G;Anastassiou CA;Koch C
通讯作者：
Koch C
影响因子：
4.2
作者：
Alessandri, B;Rice, AC;Bullock, MR
通讯作者：
Bullock, MR
影响因子：
2.5
作者：
Apartis, E;Poindessous-Jazat, FR;Bassant, MH
通讯作者：
Bassant, MH
影响因子：
4.2
作者：
Atlan, Lorre S.;Margulies, Susan S.
通讯作者：
Margulies, Susan S.
影响因子：
5.3
作者：
Cornwell, Brian R.;Johnson, Linda L.;Grillon, Christian
通讯作者：
Grillon, Christian