Commensal Staphylococcus epidermidis contributes to skin barrier homeostasis by generating protective ceramides.
Commensal Staphylococcus epidermidis contributes to skin barrier homeostasis by generating protective ceramides.
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DOI：
10.1016/j.chom.2022.01.004
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发表时间：
2022-03-09
影响因子：
30.3
通讯作者：
Otto M
中科院分区：
文献类型：
--
作者：
Zheng Y;Hunt RL;Villaruz AE;Fisher EL;Liu R;Liu Q;Cheung GYC;Li M;Otto M
以前被认为是微不足道或担心的潜在感染源，生活在我们皮肤上的细菌越来越多地被认为有益于人类健康。皮肤共生体调节粘膜免疫防御并直接干扰病原体;然而，它们对皮肤的物理完整性的贡献还不太清楚。在这里，我们表明，丰富的皮肤表皮葡萄球菌有助于皮肤屏障的完整性。S.表皮分泌一种鞘磷脂酶，为细菌获取必需的营养，但也帮助宿主产生神经酰胺，神经酰胺是防止皮肤脱水和衰老的上皮屏障的主要成分。在小鼠模型中，S. epidermidis以完全依赖于其鞘磷脂酶的方式显著增加皮肤神经酰胺水平并防止受损皮肤的水分流失。我们的发现揭示了一种共生机制，证明了皮肤微生物群在维持皮肤保护屏障中的重要作用。神经酰胺是防止皮肤脱水和老化的皮肤屏障的关键成分。Zheng等人表明，丰富的皮肤表皮葡萄球菌分泌鞘磷脂酶，促进宿主产生神经酰胺，以帮助保持皮肤完整性并防止受损皮肤的水分流失。
Previously either regarded as insignificant or feared as potential sources of infection, the bacteria living on our skin are increasingly recognized to benefit human health. Skin commensals modulate mucosal immune defenses and directly interfere with pathogens; however, their contribution to the skin’s physical integrity is less understood. Here we show that the abundant skin commensal Staphylococcus epidermidis contributes to skin barrier integrity. S. epidermidis secretes a sphingomyelinase that acquires essential nutrients for the bacteria but also assists the host in producing ceramides, the main constituent of the epithelial barrier that averts skin dehydration and aging. In mouse models, S. epidermidis significantly increases skin ceramide levels and prevents water loss of damaged skin in a fashion entirely dependent on its sphingomyelinase. Our findings reveal a symbiotic mechanism that demonstrates an important role of the skin microbiota in the maintenance of the skin’s protective barrier. Ceramides are a key constituent of the skin barrier that prevent skin dehydration and aging. Zheng et al. show that the abundant skin commensal Staphylococcus epidermidis secretes a sphingomyelinase that facilitates host production of ceramides to help maintain skin integrity and prevent water loss of damaged skin.
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影响因子：
2.9
作者：
Herrera A;Vu BG;Stach CS;Merriman JA;Horswill AR;Salgado-Pabón W;Schlievert PM
通讯作者：
Schlievert PM
与痤疮相关的人皮肤微生物组中的痤疮丙酸杆菌菌株群体。
影响因子：
6.5
作者：
Fitz-Gibbon, Sorel;Tomida, Shuta;Chiu, Bor-Han;Lin Nguyen;Du, Christine;Liu, Minghsun;Elashoff, David;Erfe, Marie C.;Loncaric, Anya;Kim, Jenny;Modlin, Robert L.;Miller, Jeff F.;Sodergren, Erica;Craft, Noah;Weinstock, George M.;Li, Huiying
通讯作者：
Li, Huiying
影响因子：
3.6
作者：
Jensen, JM;Förl, M;Schütze, S
通讯作者：
Schütze, S
影响因子：
6.5
作者：
IMOKAWA, G;ABE, A;HIDANO, A
通讯作者：
HIDANO, A
影响因子：
3.6
作者：
Heilmann, C;Schweitzer, O;Gotz, F
通讯作者：
Gotz, F