Effect of prenatal exposure to polychlorinated biphenyls on incidence of acute respiratory infections in preschool Inuit children.
Effect of prenatal exposure to polychlorinated biphenyls on incidence of acute respiratory infections in preschool Inuit children.
复制标题
产前接触多氯联苯对学龄前因纽特儿童急性呼吸道感染发病率的影响。
DOI：
10.1289/ehp.8683
复制
发表时间：
2006-08
影响因子：
10.4
通讯作者：
Ayotte, Pierre
中科院分区：
文献类型：
--
作者：
Dallaire, Frederic;Dewailly, Eric;Vezina, Carole;Muckle, Gina;Weber, Jean-Philippe;Bruneau, Suzanne;Ayotte, Pierre
关键词：
我们着手评估环境产前暴露于多氯联苯（PCB）是否与学龄前因纽特儿童急性呼吸道感染的发病率相关。我们回顾了343名0至5岁儿童的病历，并评估了脐带血浆中PCB-153浓度与急性中耳炎（AOM）和上、下呼吸道感染（URTI和LRTI）发病率之间的关系。AOM和LRTI的发生率与产前暴露于PCBs呈正相关。与第一个四分位数暴露的儿童（最少暴露）相比，第四个四分位数暴露的儿童（最多暴露）AOM和LRTI的比率分别为1.25（p < 0.001）和1.40（p < 0.001）。产前PCB暴露与上呼吸道感染发病率或住院率之间无相关性。产前接触多氯联苯可能是造成这一人群儿童呼吸道感染的重要原因。
We set out to assess whether environmental prenatal exposure to polychlorinated biphenyls (PCBs) is associated with incidence of acute respiratory infections in preschool Inuit children. We reviewed the medical charts of 343 children from 0 to 5 years of age and evaluated the associations between PCB-153 concentration in umbilical cord plasma and the incidence rates of acute otitis media (AOM) and of upper and lower respiratory tract infections (URTIs and LRTIs, respectively). The incidence rates of AOM and LRTIs were positively associated with prenatal exposure to PCBs. Compared with children in the first quartile of exposure (least exposed), children in fourth quartile (most exposed) had rate ratios of 1.25 (p < 0.001) and 1.40 (p < 0.001) for AOM and LRTIs, respectively. There was no association between prenatal PCB exposure and incidence rate of URTIs or hospitalization. Prenatal exposure to PCBs could be responsible for a significant portion of respiratory infections in children of this population.
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影响因子：
8.8
作者：
Ayotte, P;Dewailly, E;Lebel, G
通讯作者：
Lebel, G
DOI：
10.1016/s0165-5876(97)00147-x
发表时间：
1998-01-01
影响因子：
1.5
作者：
Bluestone, CD
通讯作者：
Bluestone, CD
DOI：
10.1080/15287398209530156
发表时间：
1982-01-01
期刊：
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH
影响因子：
--
作者：
CHANG, KJ;HSIEH, KH;LEE, TP
通讯作者：
LEE, TP
影响因子：
12.7
作者：
Holman, RC;Curns, AT;Schonberger, LB
通讯作者：
Schonberger, LB
影响因子：
6.4
作者：
Karron, RA;Singleton, RJ;Harrison, LH
通讯作者：
Harrison, LH