Progress toward a universal biomedical data translator.
Progress toward a universal biomedical data translator.
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DOI：
10.1111/cts.13301
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发表时间：
2022-08
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
临床、生物医学和转化科学在现有数据的广度和多样性以及这些数据对改善人类健康和福祉的潜在影响方面已经达到了一个拐点。然而，由于专业术语和表示的差异，这些数据往往是孤立的、无组织的，并且不能广泛访问。为了应对这些挑战，生物医学数据翻译联盟开发并测试了一个基于知识图谱的试点“翻译”系统，该系统能够整合现有的生物医学数据集，并将这些数据“翻译”成旨在增强人类推理和加速转化科学的见解。在证明了Translator系统的可行性之后，Translator项目已经进入了开发阶段，并且Translator联盟在研究、设计和实施操作系统方面取得了重大进展。在这里，我们描述了当前系统的架构、性能和结果质量。我们将翻译应用于与主题专家合作开发的几个真实世界的用例。最后，我们讨论了Translator的科学和技术特征，并将这些特征与其他最先进的基于生物医学图形的问答系统进行了比较。
Clinical, biomedical, and translational science has reached an inflection point in the breadth and diversity of available data and the potential impact of such data to improve human health and well‐being. However, the data are often siloed, disorganized, and not broadly accessible due to discipline‐specific differences in terminology and representation. To address these challenges, the Biomedical Data Translator Consortium has developed and tested a pilot knowledge graph‐based “Translator” system capable of integrating existing biomedical data sets and “translating” those data into insights intended to augment human reasoning and accelerate translational science. Having demonstrated feasibility of the Translator system, the Translator program has since moved into development, and the Translator Consortium has made significant progress in the research, design, and implementation of an operational system. Herein, we describe the current system’s architecture, performance, and quality of results. We apply Translator to several real‐world use cases developed in collaboration with subject‐matter experts. Finally, we discuss the scientific and technical features of Translator and compare those features to other state‐of‐the‐art, biomedical graph‐based question‐answering systems.
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DOI：
10.1111/cts.12592
发表时间：
2019-03
期刊：
Clinical and translational science
影响因子：
--
作者：
Biomedical Data Translator Consortium
通讯作者：
Biomedical Data Translator Consortium
影响因子：
14.9
作者：
Davis AP;Grondin CJ;Johnson RJ;Sciaky D;McMorran R;Wiegers J;Wiegers TC;Mattingly CJ
通讯作者：
Mattingly CJ
DOI：
10.1111/cts.13302
发表时间：
2022-08
期刊：
Clinical and translational science
影响因子：
--
作者：
通讯作者：
--
影响因子：
2.4
作者：
Rowley, Jennifer
通讯作者：
Rowley, Jennifer
影响因子：
9.8
作者：
Wilkinson MD;Dumontier M;Aalbersberg IJ;Appleton G;Axton M;Baak A;Blomberg N;Boiten JW;da Silva Santos LB;Bourne PE;Bouwman J;Brookes AJ;Clark T;Crosas M;Dillo I;Dumon O;Edmunds S;Evelo CT;Finkers R;Gonzalez-Beltran A;Gray AJ;Groth P;Goble C;Grethe JS;Heringa J;'t Hoen PA;Hooft R;Kuhn T;Kok R;Kok J;Lusher SJ;Martone ME;Mons A;Packer AL;Persson B;Rocca-Serra P;Roos M;van Schaik R;Sansone SA;Schultes E;Sengstag T;Slater T;Strawn G;Swertz MA;Thompson M;van der Lei J;van Mulligen E;Velterop J;Waagmeester A;Wittenburg P;Wolstencroft K;Zhao J;Mons B
通讯作者：
Mons B