Age of exposure-dependent effects of amphetamine on behavioral flexibility.
Age of exposure-dependent effects of amphetamine on behavioral flexibility.
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DOI：
10.1016/j.bbr.2013.06.002
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发表时间：
2013-09-01
影响因子：
2.7
通讯作者：
Gulley, Joshua M.
中科院分区：
文献类型：
--
作者：
Hankosky, Emily R.;Kofsky, Nikki M.;Gulley, Joshua M.
Drug use typically begins during adolescence, which is a period of ongoing neurobiological development that may confer heightened vulnerability to develop drug dependence. Previously, our lab has shown that amphetamine (AMPH)-induced deficits in a medial prefrontal cortex (mPFC)-sensitive working memory task are greater in rats exposed to the drug during adolescence compared to adulthood. Here, we examine potential age-dependent effects of AMPH exposure on behavioral flexibility tasks that are sensitive to disruptions in mPFC and orbitofrontal cortex (OFC) function. Male Sprague-Dawley rats were injected (i.p.) with saline or 3 mg/kg AMPH every other day between postnatal days (PNDs) 27–45 and PNDs 85–103. Starting around PND 125, rats were tested in an attentional set-shifting task and a subset of those was then tested in an operant strategy shifting task. Following completion of the operant task, rats were challenged with 3 mg/kg AMPH and monitored in open field chambers. Our results demonstrate that AMPH-exposed rats were faster to acquire simple and compound discriminations, but were impaired during the first stimulus-reward reversal when compared to controls. In the operant strategy shifting task, adolescent-exposed rats shifted more rapidly between strategies and completed reversals faster than adult-exposed and control rats, respectively. The final AMPH challenge revealed evidence for sensitization in drug pre-exposed rats, with adult-exposed animals exhibiting the most significant effects. Together, these results suggest that AMPH induces long-lasting changes in behavioral flexibility that are at least partially dependent on age of exposure and may be due to adaptations in OFC function.
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影响因子：
3.4
作者：
Fletcher, PJ;Tenn, CC;Kapur, S
通讯作者：
Kapur, S
影响因子：
5.3
作者：
Black, Yolanda D.;Maclaren, Fair R.;Konradi, Christine
通讯作者：
Konradi, Christine
影响因子：
3.4
作者：
Chase, E. Alexander;Tait, David S.;Brown, Verity J.
通讯作者：
Brown, Verity J.
影响因子：
1.7
作者：
Andersen, SL;Rutstein, M;Teicher, MH
通讯作者：
Teicher, MH
DOI：
10.1523/jneurosci.2820-08.2008
发表时间：
2008-10-29
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bissonette GB;Martins GJ;Franz TM;Harper ES;Schoenbaum G;Powell EM
通讯作者：
Powell EM