Effects of glucocorticoids on glutamine metabolism in visceral organs.
Effects of glucocorticoids on glutamine metabolism in visceral organs.
复制标题
糖皮质激素对内脏器官谷氨酰胺代谢的影响。
DOI：
10.1016/0026-0495(85)90211-2
复制
发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Wilmore,DW
中科院分区：
文献类型：
--
作者：
Souba,WW;Smith,RJ;Wilmore,DW
研究了地塞米松对器官间谷氨酰胺交换的影响，以进一步了解分解代谢疾病后氮代谢的变化。除了研究谷氨酰胺，运输高达40%的全血氨基酸氮，我们确定了谷氨酸，丙氨酸和葡萄糖的流量在胃肠道，肝脏和肾脏在25个清醒的，长期插管的狗。在对照期和地塞米松（DEX）治疗（0.44 mg/kg ·d）2天（DEX 2）和9天（DEX 9）后进行研究。地塞米松治疗后，谷氨酰胺和谷氨酸的动脉浓度下降，而丙氨酸和葡萄糖水平增加。DEX 2组和DEX 9组谷氨酰胺的摄取量分别为对照组的0.96 ± 0.13μmol/kg ·min和2.23 ± 0.24 μ mol/kg ·min（P< 0.001）和1.59 ± 0.20 μ mol/kg·min（P< 0.05）。对照组小肠释放丙氨酸（1.96 ± 0.30 μmol/kg ·min），DEX 2组释放速率增加2倍（4.10 ± 0.66，P < 0.01）。在对照状态和DEX治疗后，肝脏对谷氨酰胺的摄取保持平衡，而DEX治疗后肾脏谷氨酰胺摄取和肾脏葡萄糖释放显著增加。糖皮质激素影响胃肠道、肝脏和肾脏中的氨基酸和葡萄糖代谢。肠对糖皮质激素的反应中谷氨酰胺提取和丙氨酸产生的显著增加表明，胃肠道氨基酸代谢的改变可能有助于分解代谢疾病期间发生的低谷氨酰胺水平和加速的肠异生。
The effect of dexamethasone on interorgan glutamine exchange was studied in order to gain further understanding of the changes in nitrogen metabolism that occur following catabolic illness. In addition to studying glutamine, which transports as much as 40% of whole blood amino acid nitrogen, we determined the fluxes of glutamate, alanine, and glucose across the gastrointestinal tract, liver, and kidneys in 25 awake, chronically-catheterized dogs. Studies were performed during a control period and after dexamethasone (DEX) treatment (0.44 mg/kg · day) for two (DEX 2) and nine (DEX 9) days. Following dexamethasone treatment, arterial concentration of glutamine and glutamate fell, while alanine and glucose levels increased. Glutamine uptake by the intestine doubled with DEX (control 0.96 ± 0.13μmol/kg · minv2.23 ± 0.24 on DEX 2,P< 0.001, and 1.59 ± 0.20 on DEX 9,P< 0.05). Alanine was produced by the intestine in controls (1.96 ± 0.30 μmol/kg · minute), and release rate increased twofold on DEX 2 (4.10 ± 0.66,P< 0.01). The liver remained in balance for glutamine during both the control state and following DEX treatment, while renal glutamine uptake and renal glucose release were significantly increased after DEX. Glucocorticoids influence amino acid and glucose metabolism in the gastrointestinal tract, liver, and kidneys. The marked increase in glutamine extraction and alanine production by the intestine in response to glucocorticoids suggests that altered gastrointestinal amino acid metabolism may contribute to both the low glutamine levels and the accelerated gluconeogenesis that occur during catabolic illness.
登录
查看更多内容
手术应激中 17-酮类固醇和皮质类固醇的排泄模式。
DOI：
10.1530/acta.0.0180201
发表时间：
1955
期刊：
Acta endocrinologica
影响因子：
--
作者：
G. Birke;C. Franksson;L. Plantin
通讯作者：
L. Plantin
谷氨酰胺和尿素之间的氨分配：代谢性酸中毒的器官间参与。
影响因子：
19.6
作者：
Phromphetcharat,V;Jackson,A;Dass,PD;Welbourne,TC
通讯作者：
Welbourne,TC
影响因子：
4.8
作者：
DAVIS, JO;HOWELL, DS
通讯作者：
HOWELL, DS
正常和酸中毒大鼠谷氨酰胺代谢的器官间关系。
DOI：
10.1152/ajpendo.1981.240.5.e519
发表时间：
1981
期刊：
The American journal of physiology
影响因子：
--
作者：
Schrock,H;Goldstein,L
通讯作者：
Goldstein,L
糖皮质激素对骨骼肌谷氨酰胺代谢的影响。
DOI：
10.1152/ajpendo.1984.247.1.e75
发表时间：
1984
期刊：
The American journal of physiology
影响因子：
--
作者：
Muhlbacher,F;Kapadia,CR;Colpoys,MF;Smith,RJ;Wilmore,DW
通讯作者：
Wilmore,DW