NTS Catecholamine Neurons Mediate Hypoglycemic Hunger via Medial Hypothalamic Feeding Pathways.
NTS Catecholamine Neurons Mediate Hypoglycemic Hunger via Medial Hypothalamic Feeding Pathways.
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DOI：
10.1016/j.cmet.2019.11.016
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发表时间：
2020-02-04
期刊：
影响因子：
29
通讯作者：
Atasoy, Deniz
中科院分区：
文献类型：
--
作者：
Aklan, Iltan;Atasoy, Nilufer Sayar;Yavuz, Yavuz;Ates, Tayfun;Coban, Ilknur;Koksalar, Fulya;Filiz, Gizem;Topcu, Iskalen Cansu;Oncul, Merve;Dilsiz, Pelin;Cebecioglu, Utku;Alp, Muhammed Ikbal;Yilmaz, Bayram;Davis, Deborah R.;Hajdukiewicz, Karolina;Saito, Kenji;Konopka, Witold;Cui, Huxing;Atasoy, Deniz
葡萄糖是大脑的重要能量来源，由能量剥夺或治疗药物引发的葡萄糖缺乏可能是致命的。增加食欲是对抗低血糖的关键行为防御；然而，所涉及的中心途径尚不清楚。在这里，我们描述了来自孤束核（NTS）表达酪氨酸羟化酶（TH）的神经元的糖皮质激素喂养途径，该神经元密集地投射到下丘脑，并通过表达刺鼠相关肽（AgRP）和阿片黑皮质素原（POMC）的神经元的双向肾上腺素能调节来引发喂养。弓状核 (ARC) 投射的 NTSTH 神经元或其靶标 AgRP 神经元的急性化学遗传学抑制，会损害 2-脱氧-D-葡萄糖 (2DG) 注射诱导的糖缺乏摄食。神经解剖学追踪结果表明，ARC 投射的促食欲 NTSTH 神经元与投射到臂旁核 (PBN) 的邻近儿茶酚胺神经元有很大不同，后者可促进饱腹感。总的来说，我们描述了一种回路组织，其中来自脑干的上行通路通过下丘脑中的关键饥饿神经元刺激食欲，以应对低血糖。增加食欲是预防低血糖的关键防线。阿克兰等人。已经确定了从脑干到下丘脑的上行通路，这是低血糖引起的食物摄入所需的。
Glucose is the essential energy source for the brain, whose deficit, triggered by energy deprivation or therapeutic agents, can be fatal. Increased appetite is the key behavioral defense against hypoglycemia; however, the central pathways involved are not well understood. Here, we describe a glucoprivic feeding pathway by tyrosine hydroxylase (TH)-expressing neurons from nucleus of solitary tract (NTS), which project densely to the hypothalamus and elicit feeding through bidirectional adrenergic modulation of agouti-related peptide (AgRP)- and proopiomelanocortin (POMC)-expressing neurons. Acute chemogenetic inhibition of arcuate nucleus (ARC)-projecting NTSTH neurons or their target, AgRP neurons, impaired glucoprivic feeding induced by 2-Deoxy-D-glucose (2DG) injection. Neuroanatomical tracing results suggested that ARC-projecting orexigenic NTSTH neurons are largely distinct from neighboring catecholamine neurons projecting to parabrachial nucleus (PBN) that promotes satiety. Collectively, we describe a circuit organization in which an ascending pathway from brainstem stimulates appetite through key hunger neurons in the hypothalamus in response to hypoglycemia. Increased appetite is a key line of defense against hypoglycemia. Aklan et al. have identified an ascending pathway from the brainstem to the hypothalamus that is required for hypoglycemia-induced food intake.
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影响因子：
29
作者：
Blouet C;Schwartz GJ
通讯作者：
Schwartz GJ
DOI：
10.1152/ajpregu.00604.2003
发表时间：
2004-07-01
影响因子：
2.8
作者：
Blevins, JE;Schwartz, MW;Baskin, DG
通讯作者：
Baskin, DG
影响因子：
4.8
作者：
Gyengesi, Erika;Liu, Zhong-Wu;Diano, Sabrina
通讯作者：
Diano, Sabrina
影响因子：
64.8
作者：
Hsu, Jer-Yuan;Crawley, Suzanne;Allan, Bernard B. .
通讯作者：
Allan, Bernard B. .
影响因子：
56.9
作者：
FLYNN, FW;GRILL, HJ
通讯作者：
GRILL, HJ