A Boundary Value Approach to Optimization with an Application to Salmonella Competition
A Boundary Value Approach to Optimization with an Application to Salmonella Competition
复制标题
应用于沙门氏菌竞争的优化边界值方法
DOI：
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发表时间：
2015
影响因子：
3.5
通讯作者：
J. Rubin
中科院分区：
文献类型：
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作者：
G. Young;B. Ermentrout;J. Rubin
我们开发了一个新的优化框架来研究生态竞争过程中的策略。优化方法使用动力系统的理论，描述了基于初始条件，我们使用数值边值问题实现的一个可调系统的渐近行为。作为我们的方法的应用，我们开发了鼠伤寒沙门氏菌和宿主的原生微生物群落之间的竞争模型，这些微生物群落不断密集地栖息在大多数哺乳动物的肠道内壁。S.鼠伤寒杆菌以两种不同的表型种群侵入肠道，一种是毒性的，一种是无毒的，尽管无毒的细菌具有激活毒力因子的能力，从而“转换”成毒性种群。与直觉相反，一些研究发现，S。在毒性亚群引起身体的炎症防御后，鼠伤寒杆菌获得了比肠道微生物群更大的环境优势。我们的模型代表了肠道微生物群，无毒saltophila，和有毒saltophila人口之间的竞争，并纳入了一个简单的代表性的免疫反应。我们使用我们的模型来预测最佳策略，这将有利于saltenin在其竞争与肠道细菌。
We develop a novel optimization framework to study strategies in ecological competition processes. The optimization method uses theory from dynamical systems describing the asymptotic behavior of a bistable system based on initial conditions, which we implement using a numerical boundary value problem. As an application of our method, we develop a model of the competition between Salmonella Typhimurium and the host’s native microflora, which constantly and densely inhabit the intestinal lining of most mammals. S. Typhimurium invades the gut in two distinct phenotypic populations, one virulent and one avirulent, though the avirulent bacteria have the ability to activate a virulence factor and thereby “switch” into the virulent population. Counterintuitively, some studies have found that the combined population of S. Typhimurium gains an environmental advantage over the commensal microbiota after the virulent subpopulation provokes the body’s inflammatory defenses. Our model represents the competition between the commensal microbiota, the avirulent salmonella, and the virulent salmonella populations and incorporates a simple representation of the immune response. We use our model to predict optimal strategies that would favor salmonella in its competition with the commensal bacteria.
影响因子：
2
作者：
Day, Judy;Rubin, Jonathan;Clermont, Gilles
通讯作者：
Clermont, Gilles
发炎的肠道，沙门氏菌风格的生活。
影响因子：
15.9
作者：
Santos RL;Raffatellu M;Bevins CL;Adams LG;Tükel C;Tsolis RM;Bäumler AJ
通讯作者：
Bäumler AJ
DOI：
10.1073/pnas.83.14.5189
发表时间：
1986-07-01
影响因子：
11.1
作者：
FIELDS, PI;SWANSON, RV;HEFFRON, F
通讯作者：
HEFFRON, F