Synergistic association of high-sensitivity C-reactive protein and body mass index with insulin resistance in non-diabetic adults.
Synergistic association of high-sensitivity C-reactive protein and body mass index with insulin resistance in non-diabetic adults.
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DOI：
10.1038/s41598-020-75390-1
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发表时间：
2020-10-28
影响因子：
4.6
通讯作者：
Park EC
中科院分区：
文献类型：
--
作者：
Kim GR;Choi DW;Nam CM;Jang SI;Park EC
流行病学证据表明，炎症标志物和肥胖与胰岛素抵抗（IR）密切相关。然而，有一个评估hs-CRP升高和体重指数（BMI）之间的复杂的相互作用的研究，特别是在亚洲人的研究很少。本研究使用第7次韩国国民健康和营养检查调查（2016-2018）的横断面数据，研究了hs-CRP和BMI对IR的叠加相互作用。共5706名男性和6707名女性，年龄在20岁或以上，进行了评估，并采用多元Logistic回归分析，以评估血清hs-CRP和BMI与IR的关联，如测量的葡萄糖-葡萄糖指数（TyG指数）。使用性别特异性中位数将连续TyG指数变量二分为胰岛素敏感和IR类别。使用相互作用引起的相对超额风险（RERI）、相互作用引起的可归因比例（AP）和协同指数（SI）评价生物相互作用。高hs-CRP和超重/肥胖对IR的联合影响大于单独暴露的影响。相对于低hs-CRP和BMI < 23的患者，两种暴露均与IR增加相关，男性校正OR为2.97（95%CI 2.50-3.52），女性为3.08（95%CI 2.67-3.56），具有显著的相加作用。这些研究结果表明，减少全身炎症和BMI的IR预防策略可能超过分别针对这些风险因素的预期益处。
Epidemiological evidence has indicated that inflammatory markers and obesity are strongly correlated with insulin resistance (IR). However, there is a paucity of studies assessing the complex interaction between elevated hs-CRP and body mass index (BMI), particularly among Asians. This study investigated the additive interaction between hs-CRP and BMI on IR, using cross-sectional data from the 7th Korea National Health and Nutrition Examination Survey (2016–2018). A total of 5706 men and 6707 women aged 20 years or older were evaluated, and a multiple logistic regression analysis was used to assess the association of serum hs-CRP and BMI with IR, as measured by the triglyceride-glucose index (TyG index). Sex-specific median values were used to dichotomise the continuous TyG index variable into insulin-sensitive and IR categories. Biological interaction was evaluated using the Relative excess risk due to interaction (RERI), attributable proportion due to interaction (AP), and synergy index (SI). The joint effects of high hs-CRP and overweight/obesity on IR were greater than would be expected from the effects of the individual exposures alone. Relative to those with low hs-CRP and BMI < 23, having both exposures was related to increased IR with an adjusted OR of 2.97 (95% CI 2.50–3.52) in men and 3.08 (95% CI 2.67–3.56) in women with significant additive interactions. These findings demonstrate that IR prevention strategies that reduce both systematic inflammation and BMI may exceed the expected benefits based on targeting these risk factors separately.
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影响因子：
3.7
作者：
Er LK;Wu S;Chou HH;Hsu LA;Teng MS;Sun YC;Ko YL
通讯作者：
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Yoon, K-H
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通讯作者：
Sowers, JR
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作者：
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通讯作者：
Ahlbom, A