A nerve model of greatly increased energy-efficiency and encoding flexibility over the Hodgkin-Huxley model.
A nerve model of greatly increased energy-efficiency and encoding flexibility over the Hodgkin-Huxley model.
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DOI：
10.1016/j.brainres.2009.06.101
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发表时间：
2009-11-03
期刊：
影响因子：
2.9
通讯作者：
Fohlmeister JF
中科院分区：
文献类型：
--
作者：
Fohlmeister JF
哺乳动物“RGC模型”（视网膜神经节细胞）与Hodgkin-Huxley模型的区别在于在动作电位的再生（上升）阶段期间实际上不存在K电流，并且在再生（上升）阶段之后实际上不存在Na电流。Na-和K-电流保持可忽略不计的整个interspike间隔，其控制，因此放弃刺激电流。这些特性产生了高度灵活和节能的神经脉冲编码器。相比之下，对于Hodgkin-Huxley模型，只有15%的Na离子在动作电位期间再生地进入轴突（鱿鱼巨轴突）;浪费的85%在下降阶段进入。此外，K-电流的早期激活导致动作电位的Na-和K-电流在控制阈下膜电位（峰间间期）中占主导地位。这一特性使得Hodgkin-Huxley模型成为一个难以处理的高频振荡器，无法转换为灵活的脉冲编码。鱿鱼巨轴突（6.3° C）和RGCs（37° C）之间的温差通过Q10分析桥接，这表明高Q10的额外分子门控机制-鱿鱼中不存在-在RGCs中是活跃的。
A mammalian “RGC model” (retinal ganglion cells) is distinguished from the Hodgkin-Huxley model by the virtual absence of K-current during, and the virtual absence of Na-current after, the regenerative (rising) phase of the action potential. Both Na- and K-currents remain negligible throughout the interspike interval, whose control is therefore relinquished to stimulus currents. These properties yield a highly flexible and energy-efficient nerve impulse encoder. For the Hodgkin-Huxley model, in contrast, only 15 % of the Na-ions enter the axon regeneratively during the action potential (squid giant axon); a wasteful 85 % enter during the falling phase. Further, early activation of K-current causes the Na- and K-currents of the action potential to dominate over stimulus currents in controlling the sub-threshold membrane potential (interspike interval). This property makes the Hodgkin-Huxley model an intractable high frequency oscillator, which cannot be converted to flexible impulse encoding. The temperature difference between the squid giant axon (6.3° C) and RGCs (37° C) is bridged by a Q10 analysis, which suggests that an additional molecular gating mechanism of high Q10 – which is not present in the squid – is active in RGCs.
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