Cutting edge: Immunity against a "silent" salivary antigen of the Lyme vector Ixodes scapularis impairs its ability to feed.
Cutting edge: Immunity against a "silent" salivary antigen of the Lyme vector Ixodes scapularis impairs its ability to feed.
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最前沿：针对莱姆病媒介肩胛硬蜱的“沉默”唾液抗原的免疫力会削弱其进食能力。
DOI：
10.4049/jimmunol.181.8.5209
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发表时间：
2008-10-15
影响因子：
4.4
通讯作者：
Ribeiro, Jose M. C.
中科院分区：
文献类型：
--
作者：
Kotsyfakis, Michalis;Anderson, Jennifer M.;Andersen, John F.;Calvo, Eric;Francischetti, Ivo M. B.;Mather, Thomas N.;Valenzuela, Jesus G.;Ribeiro, Jose M. C.
Ixodes scapularis ticks transmit the Lyme disease agent in the US. Although strong anti-tick immunity mediates tick rejection by certain vertebrates, only a few antigens have been molecularly characterized. We show that guinea pig vaccination against a secreted tick salivary immunomodulator—sialostatin L2—can lead to decreased feeding ability of I. scapularis nymphs. Increased rejection rate, prolonged feeding time and apparent signs of inflammation were observed for nymphs attached to vaccinated animals, indicating a protective host immune response. Interestingly, sialostatin L2 humoral recognition does not take place upon repeated tick exposure in control animals, but only in the vaccinated animals that neutralize sialostatin L2 action. Therefore, we demonstrate an essential sialostatin L2 role upon nymphal infestation that can be blocked by vertebrate immunity and we propose the discovery of similarly ‘silent’ antigens towards the development of a multicomponent vaccine that will protect against tick bites and the pathogens they transmit.
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影响因子：
6.7
作者：
Labuda, Milan;Trimnell, Adama R;Lickova, Martina;Kazimirova, Maria;Davies, Gillian M;Lissina, Olga;Hails, Rosie S;Nuttall, Patricia A
通讯作者：
Nuttall, Patricia A
影响因子：
4.8
作者：
Kotsyfakis, Michalis;Karim, Shahid;Ribeiro, Jose M. C.
通讯作者：
Ribeiro, Jose M. C.
影响因子：
4.8
作者：
Kotsyfakis, Michalis;Sa-Nunes, Anderson;Ribeiro, Jose M. C.
通讯作者：
Ribeiro, Jose M. C.
DOI：
10.4269/ajtmh.1998.58.780
发表时间：
1998-06-01
影响因子：
3.3
作者：
Nazario, S;Das, S;Kantor, FS
通讯作者：
Kantor, FS
影响因子：
4
作者：
Wikel, SK
通讯作者：
Wikel, SK