Swallowing impairment in older adults: association with sensorimotor peripheral nerve function from the Health, Aging and Body Composition study.
Swallowing impairment in older adults: association with sensorimotor peripheral nerve function from the Health, Aging and Body Composition study.
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DOI：
10.1007/s40520-020-01522-2
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发表时间：
2021-01
影响因子：
4
通讯作者：
Simonsick EM
中科院分区：
文献类型：
--
作者：
Rech RS;Strotmeyer ES;Lange-Maia BS;Hugo FN;de Goulart BNG;Hilgert JB;Simonsick EM
这项研究的目的是检查感觉运动周围神经功能受损是否与老年人吞咽障碍的可能性较高有关。健康、老龄化和身体成分受试者(n=607，年龄75.8±2.7岁，55.8%女性，32.3%黑人)在第4年和第11年进行了周围神经测试，并在第4年和第15年评估了吞咽困难。用振动检测阈值和拇趾单丝(1.4-g/10-g)测试评价感觉神经功能。采用自评的方法收集患者的下肢周围神经病、吞咽困难等症状。使用分层方法进行数据分析。用非条件Logistic回归估计优势比(OR)。在第15年，108名参与者(17.8%)有吞咽障碍。在完全调整的模型中，与吞咽障碍相关的周围神经损害是麻木(OR=4.67；95%CI：2.24~9.75)和运动神经传导速度差(OR=2.26；95%CI：1.08~4.70)。其他周围神经损害与吞咽无关。在我们的前瞻性研究中，运动神经传导速度缓慢和麻木与十年后吞咽困难的可能性较高之间的联系确定了在老年人中进一步研究的一个重要领域。
The purpose of this study was to examine whether impairments in sensorimotor peripheral nerve function are associated with a higher likelihood of swallowing impairment in older adults. Health, Aging and Body Composition participants (n=607, age=75.8±2.7 years, 55.8% women, 32.3% black) underwent peripheral nerve testing at Year 4 and 11 with swallowing difficulty assessed at Year 4 and 15. Nerve conduction amplitude and velocity were measured at the peroneal motor nerve. Sensory nerve function was assessed with vibration detection threshold and monofilament (1.4-g/10-g) testing at the big toe. Symptoms of lower extremity peripheral neuropathy and difficulty swallowing were collected by self-report. Data analysis was performed using a hierarchical approach. Odds ratios (ORs) were estimated using non-conditional logistic regression. At Year 15 108 (17.8%) participants had swallowing impairments. In fully adjusted models, the peripheral nerve impairments associated with swallowing impairment were numbness (OR=4.67;95%CI:2.24–9.75) and poor motor nerve conduction velocity (OR=2.26;95%CI:1.08–4.70). Other peripheral nerve impairments were not related to swallowing. The association between slow motor nerve conduction velocity and numbness and a higher likelihood of swallowing difficulties a decade later in our prospective study identifies an important area for further investigation in older adults.
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影响因子：
7.4
作者：
Geber, Christian;Magerl, Walter;Birklein, Frank
通讯作者：
Birklein, Frank
影响因子：
4.7
作者：
Ward, Rachel E.;Boudreau, Robert M.;Strotmeyer, Elsa S.
通讯作者：
Strotmeyer, Elsa S.
影响因子：
7.7
作者：
Victora, CG;Huttly, SR;Olinto, MTA
通讯作者：
Olinto, MTA
影响因子：
3.9
作者：
Lange-Maia, Brittney S.;Newman, Anne B.;Strotmeyer, Elsa S.
通讯作者：
Strotmeyer, Elsa S.
影响因子：
1.2
作者：
RADLOFF L S
通讯作者：
RADLOFF L S