Thirteen-Year Outcomes in Very Preterm Children Associated with Diffuse Excessive High Signal Intensity on Neonatal Magnetic Resonance Imaging.
Thirteen-Year Outcomes in Very Preterm Children Associated with Diffuse Excessive High Signal Intensity on Neonatal Magnetic Resonance Imaging.
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DOI：
10.1016/j.jpeds.2018.10.016
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发表时间：
2019-03
期刊：
影响因子：
--
通讯作者：
Anderson PJ
中科院分区：
文献类型：
--
作者：
Mürner-Lavanchy IM;Kidokoro H;Thompson DK;Doyle LW;Cheong JLY;Hunt RW;Inder TE;Anderson PJ
目的：探讨新生儿核磁共振成像（MRI）白质弥漫性高信号强度（DEHSI）与13岁新生儿神经行为预后的关系。极早产儿（<30周孕龄或< 1250g出生体重）的MR图像在足月等龄时进行评估，DEHSI分为5个等级。此外，评估后心室周围十字路口的可见性。采用线性回归方法对125名13岁儿童的一般智力、记忆力、注意力、执行功能、运动能力和行为进行了测试，并与DEHSI等级相关。93%的婴儿检出DEHSI；一级21%，二级22%。三年级32%，四年级18%。所有DEHSI组的神经行为结果相似。较弱的证据表明，较高的DEHSI等级与较高的言语智商和注意力相关；较低的DEHSI分数与较好的计划能力有关。对胎龄、出生体重标准评分和性别的调整进一步削弱了这些影响。只有12名儿童的后十字路口不可见，13岁时的预后略差。几乎没有证据表明新生儿DEHSI可以作为后期损伤的敏感生物标志物。需要在更大的样本中进一步研究不可见的后心室周围十字路口的重要性。
To investigate the association between white matter diffuse excessive high signal intensity (DEHSI) on neonatal magnetic resonance imaging (MRI) in very preterm infants and neurobehavioral outcomes at the age of 13 years. MR images of very preterm children (<30 weeks’ gestational age or <1250 g birth weight) were evaluated at term-equivalent age with DEHSI classified into 5 grades. Additionally, visibility of the posterior periventricular crossroads was assessed. General intelligence, memory, attention, executive function, motor abilities and behavior were examined in 125 children at age 13 and related to DEHSI grades using linear regression. DEHSI was detected in 93% of infants; 21% grade 1, 22% grade 2. 32% grade 3, and 18% grade 4. Neurobehavioral outcomes were similar for all DEHSI groups. There was weak evidence that higher DEHSI grades related to higher verbal IQ and attention; and that lower DEHSI grades related to better planning ability. Adjustment for gestational age, birth weight standard score and sex further weakened these effects. Only 12 children had invisible posterior crossroads and showed slightly poorer outcomes at 13 years. There was little evidence that neonatal DEHSI serves as a sensitive biomarker for later impairment. Further investigation on the importance of invisible posterior periventricular crossroads in larger samples is needed.
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影响因子：
5.7
作者：
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通讯作者：
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