Oxidative stress implications for therapeutic vaccine development against Chagas disease.
Oxidative stress implications for therapeutic vaccine development against Chagas disease.
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DOI：
10.1080/14760584.2021.1969230
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发表时间：
2021-11
影响因子：
6.2
通讯作者：
Garg NJ
中科院分区：
文献类型：
--
作者：
Choudhuri S;Rios L;Vázquez-Chagoyán JC;Garg NJ
由原生动物寄生虫克氏锥虫 (T. cruzi) 引起的恰加斯病 (CD) 的发病机制涉及慢性氧化和炎症应激。在这篇综述中，我们讨论了迄今为止在治疗性疫苗开发方面的研究工作，以及氧化应激在实现有效的 CD 治疗性疫苗方面所带来的潜在挑战。本综述涵盖了 CD 克氏锥虫感染过程中活性氧产生的免疫和非免疫机制以及免疫反应模式。讨论了免疫疗法的开发工作、针对克氏锥虫的基于抗原的免疫疗法的功效以及抗氧化剂作为佐剂的作用，为开发未来的 CD 治疗策略提供了有希望的见解。施用治疗性疫苗可以通过实现快速、短暂的 1 型细胞介导的免疫刺激来对抗 CD 中持续的寄生虫血症。与此同时，辅助治疗可以在 CD 患者线粒体代谢和心肌收缩力的保护方面发挥关键作用。我们建议采用基于抗原的疫苗和小分子联合治疗来控制病理性氧化损伤，将有效保护 CD 的心脏结构和功能。
Pathogenesis of Chagas disease (CD) caused by the protozoan parasite Trypanosoma cruzi (T. cruzi) involves chronic oxidative and inflammatory stress. In this review, we discuss the research efforts in therapeutic vaccine development to date and the potential challenges imposed by oxidative stress in achieving an efficient therapeutic vaccine against CD. This review covers the immune and non-immune mechanisms of reactive oxygen species production and immune response patterns during T. cruzi infection in CD. A discussion on immunotherapy development efforts, the efficacy of antigen based immune therapies against T. cruzi, and the role of antioxidants as adjuvants is discussed to provide promising insights to developing future treatment strategies against CD. Administration of therapeutic vaccines can be a good option to confront persistent parasitemia in CD by achieving a rapid, short-lived stimulation of type 1 cell-mediated immunity. At the same time, adjunct therapies could play a critical role in the preservation of mitochondrial metabolism and cardiac muscle contractility in CD. We propose combined therapy with antigen-based vaccine and small molecules to control the pathological oxidative insult would be effective in the conservation of cardiac structure and function in CD.
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影响因子：
4.1
作者：
Arnal A;Villanueva-Lizama L;Teh-Poot C;Herrera C;Dumonteil E
通讯作者：
Dumonteil E
影响因子：
6
作者：
Chatelain E
通讯作者：
Chatelain E
影响因子：
4.8
作者：
Ba, Xueqing;Gupta, Shivali;Garg, Nisha Jain
通讯作者：
Garg, Nisha Jain
DOI：
10.1590/s0074-02762010000600018
发表时间：
2010-09-01
期刊：
Memórias do Instituto Oswaldo Cruz
影响因子：
--
作者：
Andrade, Luciana O;Galvão, Lúcia MC;Macedo, Andrea M
通讯作者：
Macedo, Andrea M
影响因子：
3.1
作者：
Bhatia, V;Sinha, M;Garg, N
通讯作者：
Garg, N