Optimal elastomeric scaffold leaflet shape for pulmonary heart valve leaflet replacement.
Optimal elastomeric scaffold leaflet shape for pulmonary heart valve leaflet replacement.
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DOI：
10.1016/j.jbiomech.2012.11.046
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发表时间：
2013-02-22
影响因子：
2.4
通讯作者：
Sacks MS
中科院分区：
文献类型：
--
作者：
Fan R;Bayoumi AS;Chen P;Hobson CM;Wagner WR;Mayer JE Jr;Sacks MS
外科肺动脉瓣置换术(PV)是先天性肺动脉瓣缺陷的一种常见治疗方法。开发新的光伏替代物的组织工程方法本质上是复杂的，需要有系统的方法来开发。利用绵羊模型进行单叶置换是一种很有吸引力的方法，因为候选材料可以在血液接触的瓣膜水平应力下进行评估，而不会受到特定瓣膜设计的混淆影响。本文提出了一种基于力学各向异性的光伏置换弹性支架的有限元模拟的小叶形状优化设计方法。采用广义冯型本构模型，将支架材料模拟为各向异性的超弹性材料。通过最小化有限元模拟得到的变形形状与本地绵羊PV叶的体外显微CT扫描之间的差异，系统地确定了满载PV替换叶的最佳形状。研究了材料各向异性、光伏根部尺寸变化和纤维取向对小叶变形的影响。现场验证表明，该方法可以指导PV置换手术中叶的形状设计。
Surgical replacement of the pulmonary valve (PV) is a common treatment option for congenital pulmonary valve defects. Engineered tissue approaches to develop novel PV replacements are intrinsically complex, and will require methodical approaches for their development. Single leaflet replacement utilizing an ovine model is an attractive approach in that candidate materials can be evaluated under valve level stresses in blood contact without the confounding effects of a particular valve design. In the present study an approach for optimal leaflet shape design based on finite element (FE) simulation of a mechanically anisotropic, elastomeric scaffold for PV replacement is presented. The scaffold was modeled as an orthotropic hyperelastic material using a generalized Fung-type constitutive model. The optimal shape of the fully loaded PV replacement leaflet was systematically determined by minimizing the difference between the deformed shape obtained from FE simulation and an ex-vivo microCT scan of a native ovine PV leaflet. Effects of material anisotropy, dimensional changes of PV root, and fiber orientation on the resulting leaflet deformation were investigated. In-situ validation demonstrated that the approach could guide the design of the leaflet shape for PV replacement surgery.
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影响因子：
2.9
作者：
Einstein DR;Del Pin F;Jiao X;Kuprat AP;Carson JP;Kunzelman KS;Cochran RP;Guccione JM;Ratcliffe MB
通讯作者：
Ratcliffe MB
影响因子：
4.6
作者：
Joyce, Erinn M.;Liao, Jun;Schoen, Frederick J.;Mayer, John E., Jr.;Sacks, Michael S.
通讯作者：
Sacks, Michael S.
DOI：
10.1115/1.2049337
发表时间：
2005-11-01
影响因子：
1.7
作者：
Sun, W;Abad, A;Sacks, MS
通讯作者：
Sacks, MS
影响因子：
4.6
作者：
Sodian, R;Hoerstrup, SP;Mayer, JE
通讯作者：
Mayer, JE
影响因子：
20.1
作者：
SWANSON, WM;CLARK, RE
通讯作者：
CLARK, RE