The association of diabetes and dementia and possible implications for nondiabetic populations.

The association of diabetes and dementia and possible implications for nondiabetic populations.
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DOI:
10.1586/ern.11.152
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发表时间:
2011-11
影响因子:
4.3
通讯作者:
Schnaider-Beeri M
Schnaider-Beeri M
中科院分区:
医学3区
文献类型:
--
作者:
Ravona-Springer R;Schnaider-Beeri M

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糖尿病和糖尿病前期状态一直被证明是认知能力下降、轻度认知障碍和痴呆的危险因素。这些发现的重要性在于,糖尿病和糖尿病相关因素是可以改变的,可能允许旨在推迟或预防痴呆症的干预措施。然而,由于糖尿病损害脑功能和认知的机制尚未完全了解,因此糖尿病控制还不能作为预防痴呆的策略在糖尿病受试者中普遍实施。目前尚不清楚哪些糖尿病相关因素对这种关系至关重要。此外,严格的糖尿病控制已被证明对某些糖尿病人群有风险。本文的目的是讨论目前对糖尿病及其某些特征与痴呆症之间关系的认识,并提出未来需要回答的问题。
Diabetes and prediabetic states have consistently been shown to be risk factors for cognitive decline, mild cognitive impairment and dementia. The importance of these findings is that diabetes and diabetes-related factors are modifiable, potentially permitting interventions aimed at postponing or preventing dementia. However, diabetes control cannot yet be implemented universally in diabetic subjects as a strategy for dementia prevention since the mechanisms by which diabetes impairs brain function and cognition are not fully understood. It is not clear which of the diabetes-related factors is crucial to this relationship. In addition, strict diabetic control has been demonstrated to carry risk for certain diabetic populations. The aim of the current article is to discuss current understanding of the relationships of diabetes and some of its characteristics with dementia, and suggest future questions to be answered.
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