Effects of shielding on the induction of 53BP1 foci and micronuclei after Fe ion exposures.
Effects of shielding on the induction of 53BP1 foci and micronuclei after Fe ion exposures.
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屏蔽对 Fe 离子暴露后 53BP1 病灶和微核诱导的影响
DOI：
10.1093/jrr/rrt078
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发表时间：
2014-01-01
影响因子：
2
通讯作者：
Zhou G
中科院分区：
文献类型：
--
作者：
Hu W;Pei H;Li H;Ding N;He J;Wang J;Furusawa Y;Hirayama R;Matsumoto Y;Liu C;Li Y;Kawata T;Zhou G
深空中的高原子序数和高能(HZE)粒子丰度低，但对空间辐射的生物效应有很大贡献。到目前为止，屏蔽是部分保护宇航员免受这些高穿透性粒子伤害的最有效方式。然而，模拟计算和测量预测，宇宙射线屏蔽产生的次级粒子产生的剂量和剂量当量占总剂量的很大一部分。在这项研究中，我们通过比较200 MeV/u铁束和屏蔽束的生物效应，研究了二次辐射对两种细胞类型和处于细胞周期不同阶段的细胞的生物效应。在屏蔽束中，用PMMA、聚乙烯(PE)或铝将铁离子束的能量从500 MeV/u降低到200 MeV/u。我们发现，与未屏蔽的200 MeV/u铁离子束相比，屏蔽能以一种依赖于细胞类型的方式增加53BP1焦点和微核的诱发率。这些发现为在屏蔽设计中考虑HZE颗粒与屏蔽材料相互作用所产生的二次颗粒的生物效应提供了实验证据。
High atomic number and high-energy (HZE) particles in deep space are of low abundance but substantially contribute to the biological effects of space radiation. Shielding is so far the most effective way to partially protect astronauts from these highly penetrating particles. However, simulated calculations and measurements have predicted that secondary particles resulting from the shielding of cosmic rays produce a significant fraction of the total dose and dose equivalent. In this study, we investigated the biological effects of secondary radiation with two cell types, and with cells exposed in different phases of the cell cycle, by comparing the biological effects of a 200 MeV/u iron beam with a shielded beam in which the energy of the iron ion beam was decreased from 500 MeV/u to 200 MeV/u with PMMA, polyethylene (PE), or aluminum. We found that beam shielding resulted in increased induction of 53BP1 foci and micronuclei in a cell-type-dependent manner compared with the unshielded 200 MeV/u Fe ion beam. These findings provide experimental proof that the biological effects of secondary particles resulting from the interaction between HZE particles and shielding materials should be considered in shielding design.
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影响因子：
10.4
作者：
Zhou T;Chou JW;Simpson DA;Zhou Y;Mullen TE;Medeiros M;Bushel PR;Paules RS;Yang X;Hurban P;Lobenhofer EK;Kaufmann WK
通讯作者：
Kaufmann WK
DOI：
10.1073/pnas.1016045108
发表时间：
2011-05-17
影响因子：
11.1
作者：
Asaithamby, Aroumougame;Hu, Burong;Chen, David J.
通讯作者：
Chen, David J.
影响因子：
3.4
作者：
Cromheecke, M;Piers, BA;Hoekstra, HJ
通讯作者：
Hoekstra, HJ
影响因子：
2.2
作者：
Lobascio, C.;Briccarello, M.;Durante, M.
通讯作者：
Durante, M.
影响因子：
3.8
作者：
Mukherjee, Bipasha;Camacho, Cristel Vanessa;Burma, Sandeep
通讯作者：
Burma, Sandeep