Associations of ghrelin with eating behaviors, stress, metabolic factors, and telomere length among overweight and obese women: preliminary evidence of attenuated ghrelin effects in obesity?
Associations of ghrelin with eating behaviors, stress, metabolic factors, and telomere length among overweight and obese women: preliminary evidence of attenuated ghrelin effects in obesity?
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DOI：
10.1016/j.appet.2014.01.011
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发表时间：
2014-05
期刊：
影响因子：
5.4
通讯作者：
Daubenmier, Jennifer
中科院分区：
文献类型：
--
作者：
Buss, Julia;Havel, Peter J.;Epel, Elissa;Line, Jue;Blackburn, Elizabeth;Daubenmier, Jennifer
Ghrelin调节动态平衡的食物摄取和享乐进食，是应激反应的中介物。此外，Ghrelin还具有代谢、心血管和抗衰老作用。这项横断面研究考察了超重(n=25)和肥胖女性(n=22)的血浆Ghrelin总量、基于3天饮食日记的卡路里摄入量、享乐饮食态度、压力相关因素和代谢因素以及白细胞端粒长度之间的关系。我们假设超重女性的血浆Ghrelin总量与饮食行为、压力、代谢、心血管和细胞老化因素有关，但肥胖女性由于血液中Ghrelin水平较低和/或对Ghrelin的中枢抵抗而不存在这种关联。之前的研究证实了肥胖者血浆生长激素水平降低，肥胖者的生长激素水平低于超重女性。在超重者中，Ghrelin与卡路里摄入量呈正相关，屈服于对美味食物的渴望，并在3天内出现较平坦的皮质醇昼夜斜率。这些关系在肥胖组中并不显著。在超重女性中，Ghrelin与胰岛素抵抗、收缩压和心率呈负相关，与端粒长度呈正相关。在肥胖者中，血浆Ghrelin浓度与胰岛素抵抗呈负相关，但与血压、心率或端粒长度无明显相关性。血浆Ghrelin总量及其与食物摄入量、享乐性进食和压力的关系在肥胖症中减少，这提供了与以下理论一致的证据：肥胖症患者对Ghrelin的中枢抵抗和Ghrelin在食欲调节中的功能可能是为了防止在食物短缺时挨饿而不是应对现代食物过剩。此外，Ghrelin与代谢和心血管健康有关，可能具有延缓衰老的作用，但这些作用在肥胖时可能会减弱。
Ghrelin regulates homeostatic food intake, hedonic eating, and is a mediator in the stress response. In addition, ghrelin has metabolic, cardiovascular, and anti-aging effects. This cross-sectional study examined associations between total plasma ghrelin, caloric intake based on 3 day diet diaries, hedonic eating attitudes, stress-related and metabolic factors, and leukocyte telomere length in overweight (n=25) and obese women (n=22). We hypothesized associations between total plasma ghrelin and eating behaviors, stress, metabolic, cardiovascular, and cell aging factors among overweight women, but not among obese women due to lower circulating ghrelin levels and/or central resistance to ghrelin. Confirming previous studies demonstrating lowered plasma ghrelin in obesity, ghrelin levels were lower in the obese compared with overweight women. Among the overweight, ghrelin was positively correlated with caloric intake, giving in to cravings for highly palatable foods, and a flatter diurnal cortisol slope across 3 days. These relationships were non-significant among the obese group. Among overweight women, ghrelin was negatively correlated with insulin resistance, systolic blood pressure, and heart rate, and positively correlated with telomere length. Among the obese subjects, plasma ghrelin concentrations were negatively correlated with insulin resistance, but were not significantly correlated with blood pressure, heart rate or telomere length. Total plasma ghrelin and its associations with food intake, hedonic eating, and stress are decreased in obesity, providing evidence consistent with the theory that central resistance to ghrelin develops in obesity and ghrelin’s function in appetite regulation may have evolved to prevent starvation in food scarcity rather than cope with modern food excess. Furthermore, ghrelin is associated with metabolic and cardiovascular health, and may have anti-aging effects, but these effects may be attenuated in obesity.
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影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
MERMELSTEIN, R
影响因子：
2.9
作者：
Adam, Tanja C.;Epel, Elissa S.
通讯作者：
Epel, Elissa S.
影响因子：
15.9
作者：
Chuang, Jen-Chieh;Perello, Mario;Zigman, Jeffrey M.
通讯作者：
Zigman, Jeffrey M.
影响因子：
5.8
作者：
Bowen, Jane;Noakes, Manny;Clifton, Peter M.
通讯作者：
Clifton, Peter M.
DOI：
10.1152/ajpendo.00057.2010
发表时间：
2010-09-01
影响因子：
5.1
作者：
Al-Massadi, O.;Crujeiras, A. B.;Seoane, L. M.
通讯作者：
Seoane, L. M.