Comparative matched-pair cohort analysis of the short-term clinical outcomes of mesenchymal stem cells versus hyaluronic acid treatments through intra-articular injections for knee osteoarthritis.
Comparative matched-pair cohort analysis of the short-term clinical outcomes of mesenchymal stem cells versus hyaluronic acid treatments through intra-articular injections for knee osteoarthritis.
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DOI：
10.1186/s40634-020-00310-1
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发表时间：
2020-11-13
影响因子：
1.8
通讯作者：
Koh YG
中科院分区：
文献类型：
--
作者：
Kim YS;Suh DS;Tak DH;Chung PK;Kwon YB;Kim TY;Koh YG
关节内注射透明质酸（HA）有望减轻膝关节骨关节炎（OA）的疼痛和改善身体功能。最近，利用间充质干细胞（MSCs）的细胞疗法已成为潜在的治疗方法。然而，很少有研究比较MSCs和HA的治疗结果。本研究旨在比较膝关节OA患者关节内注射MSCs与HA的临床和影像学结果。对209例膝关节OA患者进行回顾性筛查，以寻找那些使用MSCs或HA进行关节内注射的患者。30例MSC治疗患者（MSC组）与30例HA治疗患者（HA组）根据性别和年龄进行配对。临床结果采用视觉模拟量表（VAS）、国际膝关节文献委员会（IKDC）评分系统和Lysholm评分系统进行评估。放射学评价采用Kellgren-Lawrence （K-L）分级系统。MSC治疗在VAS、IKDC和Lysholm评分方面取得了一致的显著改善。HA组VAS评分在注射后1个月时显著降低，3个月时略有升高，注射后3个月至1年显著升高。IKDC和Lysholm评分在3个月前显著改善，但此后逐渐恶化。治疗1年后，与HA组相比，MSC组VAS （P = 0.041）、IKDC （P = 0.014）和Lysholm （P = 0.020）评分均有显著改善。少数患者K-L等级恶化，特别是HA组，但无显著差异。与HA组相比，MSC组在治疗后1年表现出更好的VAS、IKDC和Lysholm评分，尽管HA组在最初3个月的早期临床改善优于HA组。治疗研究，III级。
Intra-articular injection of hyaluronic acid (HA) has shown promises in reducing pain and improving physical function in knee osteoarthritis (OA). Recently, cell-based therapies using mesenchymal stem cells (MSCs) have emerged as potential treatments. However, few studies have compared the treatment outcomes between MSCs and HA. This study aimed to compare the clinical and radiological outcomes of intra-articular injections of MSCs versus HA in patients with knee OA. A cohort of 209 patients with knee OA were retrospectively screened for those who underwent intra-articular injections using MSCs or HA. Thirty MSC-treated patients (MSC group) were pair-matched with thirty HA-treated patients (HA group) based on gender and age. Clinical outcomes were evaluated using the visual analog scale (VAS), International Knee Documentation Committee (IKDC) rating system, and Lysholm scoring system. Radiological evaluation was assessed using the Kellgren-Lawrence (K-L) grading system. MSC treatment yielded consistent significant improvements in VAS, IKDC and Lysholm scores. In the HA group, VAS scores significantly decreased at 1 month, slightly increased at 3 months, and increased significantly from 3 months to 1 year after injection. The IKDC and Lysholm scores improved significantly until 3 months, but gradually worsened thereafter. Significantly greater improvements in VAS (P = 0.041), IKDC (P = 0.014), and Lysholm (P = 0.020) scores were observed in the MSC group compared to those in the HA group at 1-year post-treatment. The K-L grade worsened in a few patients, especially those in the HA group, albeit no significant difference. MSC group showed better VAS, IKDC, and Lysholm scores at 1-year post-treatment, compared to the HA group, although earlier clinical improvements were superior in the HA group for the initial 3 months. Therapeutic study, Level III.
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成年人类骨髓衍生，培养，合并，同种异体间质基质细胞（STEMPEUCEL®）的功效和安全性：膝关节骨关节炎中的临床前和临床试验。
影响因子：
4.9
作者：
Gupta PK;Chullikana A;Rengasamy M;Shetty N;Pandey V;Agarwal V;Wagh SY;Vellotare PK;Damodaran D;Viswanathan P;Thej C;Balasubramanian S;Majumdar AS
通讯作者：
Majumdar AS
影响因子：
4
作者：
DeCaria, Joseph E.;Montero-Odasso, Manuel;Petrella, Robert J.
通讯作者：
Petrella, Robert J.
影响因子：
--
作者：
FELSON, DT;ZHANG, YQ;LEVY, D
通讯作者：
LEVY, D
影响因子：
4.9
作者：
Boettger MK;Kümmel D;Harrison A;Schaible HG
通讯作者：
Schaible HG
影响因子：
4.8
作者：
Hyunchul, Chris;Chai, Jee Won;Yoon, Kang Sup
通讯作者：
Yoon, Kang Sup