Is fetal MRI ready for neuroimaging prime time? An examination of progress and remaining areas for development.
Is fetal MRI ready for neuroimaging prime time? An examination of progress and remaining areas for development.
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DOI：
10.1016/j.dcn.2021.100999
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发表时间：
2021-10
影响因子：
4.7
通讯作者：
Thomason ME
中科院分区：
文献类型：
--
作者：
Rajagopalan V;Deoni S;Panigrahy A;Thomason ME
设计大规模、多中心研究的一个主要挑战是开发一个核心的、可扩展的方案，该方案既要保留科学进步的创新性，又要适应各中心经验和资源的变化。在制定一项共同的健康大脑和儿童发育（HBCD）协议时，主要问题之一是“胎儿MRI是否已经准备好了？”虽然人们对通过MRI非侵入性获得的产前数据的价值达成了一致，但关于实用性的问题比比皆是。在过去的几年里，胎儿和胎盘MRI方法学取得了快速进展，但在支持大规模胎儿MRI方案方面，所获得的收益是否超过挑战还不确定。在这里，我们将定义在不同的专业知识的网站之间建立一个共同的协议固有的挑战，并提出一个暂定的框架，评估设计决策。我们将在后COVID时代的背景下，比较和对比规范人群和高风险人群的各种设计考虑。最后，我们将阐述克服这些挑战的好处，并有助于解决六溴环十二烷倡议中阐述的主要问题。
A major challenge in designing large-scale, multi-site studies is developing a core, scalable protocol that retains the innovation of scientific advances while also lending itself to the variability in experience and resources across sites. In the development of a common Healthy Brain and Child Development (HBCD) protocol, one of the chief questions is “is fetal MRI ready for prime-time?” While there is agreement about the value of prenatal data obtained non-invasively through MRI, questions about practicality abound. There has been rapid progress over the past years in fetal and placental MRI methodology but there is uncertainty about whether the gains afforded outweigh the challenges in supporting fetal MRI protocols at scale. Here, we will define challenges inherent in building a common protocol across sites with variable expertise and will propose a tentative framework for evaluation of design decisions. We will compare and contrast various design considerations for both normative and high-risk populations, in the setting of the post-COVID era. We will conclude with articulation of the benefits of overcoming these challenges and would lend to the primary questions articulated in the HBCD initiative.
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影响因子：
5.7
作者：
Batalle D;O'Muircheartaigh J;Makropoulos A;Kelly CJ;Dimitrova R;Hughes EJ;Hajnal JV;Zhang H;Alexander DC;Edwards AD;Counsell SJ
通讯作者：
Counsell SJ
影响因子：
5
作者：
Chartier, Andre L.;Bouvier, Monique J.;Marks, Robert M.
通讯作者：
Marks, Robert M.
影响因子：
5.7
作者：
Bastiani M;Cottaar M;Fitzgibbon SP;Suri S;Alfaro-Almagro F;Sotiropoulos SN;Jbabdi S;Andersson JLR
通讯作者：
Andersson JLR
影响因子：
4
作者：
Camm EJ;Botting KJ;Sferruzzi-Perri AN
通讯作者：
Sferruzzi-Perri AN
影响因子：
3.7
作者：
Clouchoux, C.;du Plessis, A. J.;Limperopoulos, C.
通讯作者：
Limperopoulos, C.