Negative emotionality: monoamine oxidase B gene variants modulate personality traits in healthy humans.
Negative emotionality: monoamine oxidase B gene variants modulate personality traits in healthy humans.
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DOI：
10.1007/s00702-009-0281-2
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发表时间：
2009-10
影响因子：
3.3
通讯作者：
de Wit, Harriet
中科院分区：
文献类型：
--
作者：
Dlugos, Andrea M.;Palmer, Abraham A.;de Wit, Harriet
关键词：
单胺氧化酶A和B（MAOA和MAOB）参与了抑郁症的发病机制，抑郁症易感性与积极和消极情感相关的人格特质有关。本研究旨在探讨健康志愿者单胺氧化酶（MAOA）和单胺氧化酶（MAOB）基因多态性与正性和负性情绪性人格特质的关系，以阐明人格与抑郁风险的内在机制。健康的高加索志愿者（N = 150）完成了多相人格问卷（MPQ），其中包括独立的超级因素的积极性和消极性。参与者进行了8个MAOA和12个MAOB单核苷酸多态性（SNP）的基因分型。使用PLINK中实现的排列方法进行SNP和单倍型的关联分析。负相关性与两个高度连锁的MAOB多态性rs 10521432和rs6651806显著相关（p < 0.002）。研究结果在单倍型分析中得到了扩展。对于MAOB，由rs 1799836、rs 10521432、rs6651806和rs 590551形成的4-SNP单倍型GACG与较低的负相关性评分显著相关（p < 0.002）。MAOA在本研究中与人格无关。我们的发现提供了第一个证据表明MAOB多态性影响健康人类志愿者的负面情绪水平。如果得到证实，这些结果可能会导致更好地了解人格特质和个体间的易感性发展的精神疾病，如抑郁症。
Monoamine oxidase A and B (MAOA and MAOB) appear to be involved in the pathogenesis of Major Depression, and vulnerability of Major Depression is associated with personality traits relating to positive and negative affect. This study aimed to investigate associations between MAOA and MAOB polymorphisms and personality traits of positive and negative emotionality in healthy volunteers, to elucidate mechanisms underlying personality and the risk for depression. Healthy Caucasian volunteers (N = 150) completed the Multiphasic Personality Questionnaire (MPQ), which includes independent superfactors of Positive Emotionality and Negative Emotionality. Participants were genotyped for 8 MAOA and 12 MAOB single nucleotide polymorphisms (SNPs). Association analyses for both SNPs and haplotypes were performed using the permutation approach implemented in PLINK. Negative Emotionality was significantly associated with the two highly linked MAOB polymorphisms rs10521432 and rs6651806 (p < 0.002). Findings were extended in haplotype analyses. For MAOB the 4-SNP haplotype GACG formed from rs1799836, rs10521432, rs6651806 and rs590551 was significantly related to lower Negative Emotionality scores (p < 0.002). MAOA was not related to personality in this study. Our finding provides the first evidence that MAOB polymorphisms influence levels of negative emotionality in healthy human volunteers. If confirmed, these results could lead to a better understanding of personality traits and inter-individual susceptibility developing psychiatric disorders such as major depression.
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影响因子：
6.7
作者：
BUCHSBAUM, MS;HAIER, RJ;MURPHY, DL
通讯作者：
MURPHY, DL
DOI：
10.1002/ajmg.b.30228
发表时间：
2005-11-05
影响因子：
2.8
作者：
Hohoff, C;McDonald, JM;de Wit, H
通讯作者：
de Wit, H
影响因子：
11.3
作者：
Cataldo, MG;Nobile, M;Molteni, M
通讯作者：
Molteni, M
影响因子：
10.6
作者：
Dlugos, Andrea;Freitag, Christine;de Wit, Harriet
通讯作者：
de Wit, Harriet
影响因子：
56.9
作者：
Caspi, A;McClay, J;Poulton, R
通讯作者：
Poulton, R