Involvement of nephrin in human placental trophoblast syncytialization.
Involvement of nephrin in human placental trophoblast syncytialization.
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去氧肾上腺素参与人胎盘滋养层合胞化。
DOI：
10.1530/rep-14-0424
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发表时间：
2015-04
期刊：
影响因子：
3.8
通讯作者：
Fu Jiejun
中科院分区：
文献类型：
--
作者：
Lin Haiyan;Wang Hongmei;Yu Xiaoguang;Fu Jiejun
胎盘具有许多功能，例如运输氧气和养分并建立胎儿的免疫耐受性。细胞融合是胎盘发育和成熟的重要过程。在人胎盘发育中，单核细胞
The placenta has numerous functions, such as transporting oxygen and nutrients and building the immune tolerance of the fetus. Cell fusion is an essential process for placental development and maturation. In human placental development, mononucleated cytotrophoblast (CTB) cells can fuse to form a multinucleated syncytiotrophoblast (STB), which is the outermost layer of the placenta. Nephrin is a transmembrane protein that belongs to the Ig superfamily. Previous studies have shown that nephrin contributes to the fusion of myoblasts into myotubes in zebrafish and mice, presenting a functional conservation with its Drosophila ortholog sticks and stones. However, whether nephrin is involved in trophoblast syncytialization remains unclear. In this study, we report that nephrin was localized predominantly in the CTB cells and STB of human placenta villi from first trimester to term pregnancy. Using a spontaneous fusion model of primary CTB cells, the expression of nephrin was found to be increased during trophoblast cell fusion. Moreover, the spontaneous syncytialization and the expression of syncytin 2, connexin 43, and human chorionic gonadotropin beta were significantly inhibited by nephrin-specific siRNAs. The above results demonstrate that nephrin plays an important role in trophoblast syncytialization.
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影响因子：
--
作者：
Yang GY;Lee KA;Park MH;Park HS;Ha EH;Chun SH;Kim YJ
通讯作者：
Kim YJ
影响因子：
4.6
作者：
Christos Coutifaris;L. Kao;H. Sehdev;U. Chin;G. O. Babalola;O W Blaschuk;Jerome F. Strauss
通讯作者：
Christos Coutifaris;L. Kao;H. Sehdev;U. Chin;G. O. Babalola;O W Blaschuk;Jerome F. Strauss
DOI：
10.1172/jci22991
发表时间：
2004-09
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
K. Red-Horse;Yan Zhou;O. Genbačev;A. Prakobphol;R. Foulk;M. Mcmaster;S. Fisher
通讯作者：
K. Red-Horse;Yan Zhou;O. Genbačev;A. Prakobphol;R. Foulk;M. Mcmaster;S. Fisher
影响因子：
9.8
作者：
Lenkkeri, U;Männikkö, M;Tryggvason, K
通讯作者：
Tryggvason, K
影响因子：
12.4
作者：
Baczyk, D.;Drewlo, S.;Kingdom, J.
通讯作者：
Kingdom, J.