Two-Dimensional Temporal Clustering Analysis for Patients with Epilepsy: Detecting Epilepsy-Related Information in EEG-fMRI Concordant, Discordant and Spike-Less Patients.
Two-Dimensional Temporal Clustering Analysis for Patients with Epilepsy: Detecting Epilepsy-Related Information in EEG-fMRI Concordant, Discordant and Spike-Less Patients.
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DOI：
10.1007/s10548-017-0598-3
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发表时间：
2018-03
期刊：
影响因子：
2.7
通讯作者：
Morgan VL
中科院分区：
文献类型：
--
作者：
Maziero D;Velasco TR;Salmon CEG;Morgan VL
EEG与fMRI同时采集（EEG-fMRI）是一种多模式方法，在定位局灶性癫痫患者的癫痫发作区方面显示出了希望。然而，有许多情况下，当这种方法是不成功的或不适用的，和其他数据驱动的功能磁共振成像方法可以利用。其中一种方法是二维时间聚类分析（2dTCA）。在这项研究中，我们比较了经典的脑电图功能磁共振成像和2dTCA的性能在映射区域相关的癫痫发作区域的18局灶性癫痫患者（12个发作间期癫痫样放电（IEDs），在脑电图功能磁共振成像采集）与恩格尔I或II手术的结果。计算2dTCA定时输出（正和负直方图）和EEG检测到的IED的激活图，并与癫痫手术切除区域进行比较。根据MRI期间检测到的EEG尖峰频率，对患者进行了三个类别的评价。5/12例受试者的EEG-fMRI图与癫痫区域一致，其中4例在EEG上有频繁的IED。2dTCA成功标测了13/18例患者，包括3/6例未检测到IED（10/12例检测到IED）。两种方法仅在4/12例患者中成功映射了癫痫相关活动。这项工作表明，每种方法检测到的癫痫相关信息可能是不同的：虽然EEG -fMRI在EEG检测到的IED数量高的患者中比在EEG检测到的IED数量低的患者中更准确;即使没有检测到并发EEG尖峰或EEG-fMRI无效，2dTCA也可用于评估患者。因此，我们的结果支持2dTCA可能是绘制阴性EEG-fMRI（6/7例患者）和无尖峰患者中癫痫相关BOLD活动的替代方案。
EEG acquired simultaneously with fMRI (EEG-fMRI) is a multimodal method that has shown promise in mapping the seizure onset zone in patients with focal epilepsy. However, there are many instances when this method is unsuccessful or not applicable, and other data driven fMRI methods may be utilized. One such method is the two-dimensional temporal clustering analysis (2dTCA). In this study we compared the classic EEG-fMRI and 2dTCA performance in mapping regions related to the seizure onset region in 18 focal epilepsy patients (12 presenting interictal epileptiform discharges (IEDs), during EEG-fMRI acquisition) with Engel I or II surgical outcome. Activation maps of both 2dTCA timing outputs (positive and negative histograms) and EEG detected IEDs were computed and compared to the region of epilepsy surgical resection. Patients were evaluated in three categories based on frequency of EEG detected spiking during the MRI. EEG-fMRI maps were concordant to the epilepsy region in 5/12 subjects, four with frequent IEDs on EEG. The 2dTCA was successful in mapping 13/18 patients including 3/6 with no IEDs detected (10/12 with IEDs detected). The epilepsy-related activities were successfully mapped by both methods in only 4/12 patients. This work suggests that the epilepsy -related information detected by each method may be different: while EEG -fMRI is more accurate in patients with high rather than lower numbers of EEG detected IEDs; 2dTCA can be useful in evaluating patients even when no concurrent EEG spikes are detected or EEG-fMRI is not effective. Therefore, our results support that 2dTCA might be an alternative for mapping epilepsy-related BOLD activity in negative EEG-fMRI(6/7 patients) and spike -less patients.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
DOI：
10.1016/j.clinph.2011.06.018
发表时间：
2012-02
期刊：
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
影响因子：
--
作者：
Caporro M;Haneef Z;Yeh HJ;Lenartowicz A;Buttinelli C;Parvizi J;Stern JM
通讯作者：
Stern JM
影响因子：
14.5
作者：
Grouiller, Frederic;Thornton, Rachel C.;Vulliemoz, Serge
通讯作者：
Vulliemoz, Serge
影响因子：
64.8
作者：
Liu, YJ;Gao, JH;Fox, PT
通讯作者：
Fox, PT
影响因子：
4.8
作者：
Morgan, Victoria L.;Gore, John C.
通讯作者：
Gore, John C.