Towards a comprehensive view of 8-oxo-7,8-dihydro-2'-deoxyguanosine: Highlighting the intertwined roles of DNA damage and epigenetics in genomic instability.
Towards a comprehensive view of 8-oxo-7,8-dihydro-2'-deoxyguanosine: Highlighting the intertwined roles of DNA damage and epigenetics in genomic instability.
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DOI：
10.1016/j.dnarep.2020.103027
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发表时间：
2021-01
期刊：
影响因子：
3.8
通讯作者：
Amente S
中科院分区：
文献类型：
--
作者：
Gorini F;Scala G;Cooke MS;Majello B;Amente S
8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG), a major product of DNA oxidation, is a pre-mutagenic lesion which is prone to mispair, if left unrepaired, with 2′-deoxyadenosine during DNA replication. While unrepaired or incompletely repaired 8-oxodG has classically been associated with genome instability and cancer, it has recently been reported to have a role in the epigenetic regulation of gene expression. Despite the growing collection of genome-wide 8-oxodG mapping studies that have been used to provide new insight on the functional nature of 8-oxodG within the genome, a comprehensive view that brings together the epigenetic and the mutagenic nature of the 8-oxodG is still lacking. To help address this gap, this review aims to provide (i) a description of the state-of-the-art knowledge on both the mutagenic and epigenetic roles of 8-oxodG; (ii) putative molecular models through which the 8-oxodG can cause genome instability; (iii) a possible molecular model on how 8-oxodG, acting as an epigenetic signal, could cause the translocations and deletions which are associated with cancer.
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影响因子：
14.9
作者：
Amente, Stefano;Di Palo, Giacomo;Majello, Barbara
通讯作者：
Majello, Barbara
影响因子：
3.3
作者：
Baik, MH;Silverman, JS;Thorp, HH
通讯作者：
Thorp, HH
影响因子：
8
作者：
D'Errico, M.;Parlanti, E.;Dogliotti, E.
通讯作者：
Dogliotti, E.
影响因子：
8.8
作者：
Cristini A;Ricci G;Britton S;Salimbeni S;Huang SN;Marinello J;Calsou P;Pommier Y;Favre G;Capranico G;Gromak N;Sordet O
通讯作者：
Sordet O
DOI：
10.1046/j.1525-1373.1999.d01-141.x
发表时间：
1999-12-01
影响因子：
--
作者：
Aust, AE;Eveleigh, JF
通讯作者：
Eveleigh, JF