Effect on Rheological Properties and 3D Printability of Biphasic Calcium Phosphate Microporous Particles in Hydrocolloid-Based Hydrogels.
Effect on Rheological Properties and 3D Printability of Biphasic Calcium Phosphate Microporous Particles in Hydrocolloid-Based Hydrogels.
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DOI：
10.3390/gels8010028
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发表时间：
2022-01-02
期刊：
影响因子：
--
通讯作者：
Aguilar E
中科院分区：
文献类型：
--
作者：
Herrada-Manchón H;Rodríguez-González D;Fernández MA;Kucko NW;Barrère-de Groot F;Aguilar E
通过3D打印生产针对患者的精确匹配的骨替代物，作为自体骨移植的替代方案正在兴起。对于组织再生的成功，材料的特性，如孔隙率、硬度和表面形貌对细胞-材料的相互作用有很大的影响，需要引起高度重视。印刷由不规则形状的微孔双相磷酸钙(BCP)颗粒(150-500微米)增强的软水胶体水凝胶是获得具有良好机械性能的复杂网络的另一种策略，可以满足细胞增殖和再生的需要。三种著名的亲水胶体(海藻酸钠、黄原胶和明胶)已与BCP颗粒结合，生成稳定、均匀和可打印的固体分散体。通过流变学评价，确定了交联时间、印花工艺参数(填充密度百分比和填充图案)、BCP颗粒大小和浓度对印花基质硬度的影响。此外，还研究了新鲜和脱水3D打印结构的溶胀行为，其中观察到BCP颗粒的特性影响结构的吸水率、颗粒向外扩散和降解性。
The production of patient-specific bone substitutes with an exact fit through 3D printing is emerging as an alternative to autologous bone grafting. To the success of tissue regeneration, the material characteristics such as porosity, stiffness, and surface topography have a strong influence on the cell–material interaction and require significant attention. Printing a soft hydrocolloid-based hydrogel reinforced with irregularly-shaped microporous biphasic calcium phosphate (BCP) particles (150–500 µm) is an alternative strategy for the acquisition of a complex network with good mechanical properties that could fulfill the needs of cell proliferation and regeneration. Three well-known hydrocolloids (sodium alginate, xanthan gum, and gelatin) have been combined with BCP particles to generate stable, homogenous, and printable solid dispersions. Through rheological assessment, it was determined that the crosslinking time, printing process parameters (infill density percentage and infill pattern), as well as BCP particle size and concentration all influence the stiffness of the printed matrices. Additionally, the swelling behavior on fresh and dehydrated 3D-printed structures was investigated, where it was observed that the BCP particle characteristics influenced the constructs’ water absorption, particle diffusion out of the matrix and degradability.
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影响因子：
3
作者：
Azam, S. M. Roknul;Zhang, Min;Yang, Chaohui
通讯作者：
Yang, Chaohui
影响因子：
5.7
作者：
Li N;Guo R;Zhang ZJ
通讯作者：
Zhang ZJ
影响因子：
10.7
作者：
Liu, Zhenbin;Bhandari, Bhesh;Zhang, Min
通讯作者：
Zhang, Min
DOI：
10.1016/j.msec.2021.112357
发表时间：
2021-08-12
影响因子：
7.9
作者：
Herrada-Manchon, Helena;Celada, Lucia;Chiara, Maria-Dolores
通讯作者：
Chiara, Maria-Dolores
影响因子：
3
作者：
Kreimendahl, Franziska;Koepf, Marius;Fischer, Horst
通讯作者：
Fischer, Horst