Bioink Formulations for Bone Tissue Regeneration.
Bioink Formulations for Bone Tissue Regeneration.
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DOI：
10.3389/fbioe.2021.630488
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发表时间：
2021
影响因子：
5.7
通讯作者：
Zhang ZJ
中科院分区：
文献类型：
--
作者：
Li N;Guo R;Zhang ZJ
与用于构建组织支架的传统技术不同，三维（3D）生物打印技术能够制造具有复杂和多样化几何形状的多孔结构，这有助于均匀分布的细胞和有序释放信号因子。到目前为止，一系列载有细胞的材料，如天然或合成聚合物，已被3D生物打印技术用于构建支架系统和再生天然细胞外基质（ECM）的替代品。四维（4D）生物打印技术最近引起了人们的广泛关注，因为它旨在适应支架的动态结构和功能转变。然而，在生物墨水制剂的合适的可加工性、水凝胶植入物的所需机械性能和生物材料的细胞引导功能性方面，仍然存在满足技术要求的挑战。本文综述了近年来生物打印技术的研究进展，讨论了基于水凝胶的生物墨水模拟天然骨组织样细胞外基质环境的策略，包括生物打印所需生物墨水配方的性质、结构要求以及坚韧水凝胶支架的制备。分析了通常用于触发支架的动态结构和功能转变的刺激机制。最后，我们强调了智能水凝胶生物墨水/支架用于骨组织再生的当前挑战和未来可能的途径。
Unlike the conventional techniques used to construct a tissue scaffolding, three-dimensional (3D) bioprinting technology enables fabrication of a porous structure with complex and diverse geometries, which facilitate evenly distributed cells and orderly release of signal factors. To date, a range of cell-laden materials, such as natural or synthetic polymers, have been deployed by the 3D bioprinting technique to construct the scaffolding systems and regenerate substitutes for the natural extracellular matrix (ECM). Four-dimensional (4D) bioprinting technology has attracted much attention lately because it aims to accommodate the dynamic structural and functional transformations of scaffolds. However, there remain challenges to meet the technical requirements in terms of suitable processability of the bioink formulations, desired mechanical properties of the hydrogel implants, and cell-guided functionality of the biomaterials. Recent bioprinting techniques are reviewed in this article, discussing strategies for hydrogel-based bioinks to mimic native bone tissue-like extracellular matrix environment, including properties of bioink formulations required for bioprinting, structure requirements, and preparation of tough hydrogel scaffolds. Stimulus mechanisms that are commonly used to trigger the dynamic structural and functional transformations of the scaffold are analyzed. At the end, we highlighted the current challenges and possible future avenues of smart hydrogel-based bioink/scaffolds for bone tissue regeneration.
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