Spider venom peptides as potential drug candidates due to their anticancer and antinociceptive activities
Spider venom peptides as potential drug candidates due to their anticancer and antinociceptive activities
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蜘蛛毒肽因其抗癌和镇痛活性而成为潜在的候选药物
DOI：
10.1590/1678-9199-jvatitd-14-63-18
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发表时间：
2019-06
影响因子：
2.4
通讯作者：
Deng Meichun
中科院分区：
文献类型：
--
作者：
Wu Ting;Wang Meng;Wu Wenfang;Luo Qianxuan;Jiang Liping;Tao Huai;Deng Meichun
Abstract Spider venoms are known to contain proteins and polypeptides that perform various functions including antimicrobial, neurotoxic, analgesic, cytotoxic, necrotic, and hemagglutinic activities. Currently, several classes of natural molecules from spider venoms are potential sources of chemotherapeutics against tumor cells. Some of the spider peptide toxins produce lethal effects on tumor cells by regulating the cell cycle, activating caspase pathway or inactivating mitochondria. Some of them also target the various types of ion channels (including voltage-gated calcium channels, voltage-gated sodium channels, and acid-sensing ion channels) among other pain-related targets. Herein we review the structure and pharmacology of spider-venom peptides that are being used as leads for the development of therapeutics against the pathophysiological conditions including cancer and pain.
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DOI：
10.1186/s40409-016-0091-6
发表时间：
2016
期刊：
The journal of venomous animals and toxins including tropical diseases
影响因子：
--
作者：
da Fonseca Pacheco D;Freitas AC;Pimenta AM;Duarte ID;de Lima ME
通讯作者：
de Lima ME
影响因子：
7.4
作者：
Dalmolin, Gerusa Duarte;Silva, Cassia Regina;Ferreira, Juliano
通讯作者：
Ferreira, Juliano
影响因子：
1.6
作者：
Wang X;Wang G
通讯作者：
Wang G
影响因子：
3.4
作者：
Finn, DP;Beckett, SRG;Chapman, V
通讯作者：
Chapman, V
影响因子：
3.6
作者：
Baskar R;Lee KA;Yeo R;Yeoh KW
通讯作者：
Yeoh KW