The latest advances on nonlinear insulator-based electrokinetic microsystems under direct current and low-frequency alternating current fields: a review

The latest advances on nonlinear insulator-based electrokinetic microsystems under direct current and low-frequency alternating current fields: a review
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直流和低频交流场下基于非线性绝缘体的动电微系统的最新进展:综述

DOI:
10.1007/s00216-021-03687-9
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发表时间:
2022
影响因子:
4.3
通讯作者:
Lapizco-Encinas, Blanca H.
Lapizco-Encinas, Blanca H.
中科院分区:
化学2区
文献类型:
--
作者:
Lapizco-Encinas, Blanca H.

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这篇综述文章概述了基于绝缘体的介电电泳 (iDEP) 领域的发展;特别是,它专注于用直流电和低频(< 1kHz)交流电场刺激的基于绝缘体的电动(iEK)系统。这篇文章介绍了 iDEP 作为一个研究领域的蓬勃发展,其中开发了许多不同的设备设计,从具有绝缘柱阵列的微通道到具有弯曲壁以及纳米和微移液器的设备。所有这些系统都可以操纵和分离从大分子到微生物的各种颗粒,包括临床和生物医学应用。最近的实验报告,在物理和胶体领域重要理论研究的支持下,引起了人们对这些系统中第二类电泳效应的关注。最近的这些发现表明,DEP 并不是粒子捕获背后的主要力量,正如过去二十年人们所认为的那样。这项新研究表明,在直流电和低频交流电势下,粒子捕获主要是由于电渗效应和电泳效应(线性和非线性)之间的平衡所致;尽管 DEP 存在于这些系统中,但它并不是主导力量。考虑到这些最近的研究,建议将该领域从 DC-iDEP 重命名为 DC-iEK(并将低频 AC-iDEP 重命名为低频 AC-iEK)。尽管仍需要进行大量研究,但这是微型 EK 系统领域的一个激动人心的时刻,因为这些新发现似乎解释了 iEK 设备中粒子迁移和捕获建模所面临的挑战,并可能提供对粒子捕获背后机制的更好理解。
This review article presents an overview of the evolution of the field of insulator-based dielectrophoresis (iDEP); in particular, it focuses on insulator-based electrokinetic (iEK) systems stimulated with direct current and low-frequency(< 1 kHz) AC electric fields. The article covers the surge of iDEP as a research field where many different device designs were developed, from microchannels with arrays of insulating posts to devices with curved walls and nano- and micropipettes. All of these systems allowed for the manipulation and separation of a wide array of particles, ranging from macromolecules to microorganisms, including clinical and biomedical applications. Recent experimental reports, supported by important theoretical studies in the field of physics and colloids, brought attention to the effects of electrophoresis of the second kind in these systems. These recent findings suggest that DEP is not the main force behind particle trapping, as it was believed for the last two decades. This new research suggests that particle trapping, under DC and low-frequency AC potentials, mainly results from a balance between electroosmotic and electrophoretic effects (linear and nonlinear); although DEP is present in these systems, it is not a dominant force. Considering these recent studies, it is proposed to rename this field from DC-iDEP to DC-iEK (and low-frequency AC-iDEP to low-frequency AC-iEK). Whereas much research is still needed, this is an exciting time in the field of microscale EK systems, as these new findings seem to explain the challenges with modeling particle migration and trapping in iEK devices, and provide perhaps a better understanding of the mechanisms behind particle trapping.
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影响因子: 2.9
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DOI: 10.1002/elps.202000233
发表时间: 2021
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影响因子: 2.9
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期刊: MICROMACHINES
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