The High Costs of Low-Grade Inflammation: Persistent Fatigue as a Consequence of Reduced Cellular-Energy Availability and Non-adaptive Energy Expenditure.
The High Costs of Low-Grade Inflammation: Persistent Fatigue as a Consequence of Reduced Cellular-Energy Availability and Non-adaptive Energy Expenditure.
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DOI：
10.3389/fnbeh.2018.00078
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发表时间：
2018
影响因子：
3
通讯作者：
Heijnen CJ
中科院分区：
文献类型：
--
作者：
Lacourt TE;Vichaya EG;Chiu GS;Dantzer R;Heijnen CJ
慢性或持续性疲劳是几种疾病常见的、使人虚弱的症状。在几种疲劳模型中，持续性疲劳与低度炎症有关，包括癌症相关性疲劳和慢性疲劳综合征。然而，目前尚不清楚低度炎症是如何导致疲劳的。我们在这里提出了一个低级别炎症导致的能量可获得性和能量消耗失衡的模型。在这篇叙述性综述中，我们讨论了慢性低度炎症如何导致细胞能量供应减少。低度炎症导致代谢从能量高效的氧化磷酸化转变为快速作用但效率较低的有氧糖酵解能量产生；增加活性氧物种；降低胰岛素敏感性。这些影响导致葡萄糖的可获得性降低，从而降低细胞能量。此外，新出现的证据表明，慢性低度炎症与在特定情况下努力的意愿增加有关。昼夜节律的变化和睡眠障碍可能会介导炎症对细胞能量供应和非适应性能量消耗的影响。在综述的第二部分，我们提出了持续性疲劳模型中这些代谢途径的证据，重点是慢性疲劳综合征和癌症相关疲劳。与疲劳相关的细胞能量供应减少的大多数证据来自对慢性疲劳综合症的研究。虽然来自癌症相关疲劳文献的机制证据仍然有限，但稀少的结果也表明细胞能量的可获得性降低。也有越来越多的证据表明，持续性疲劳患者的行为能量消耗超过了减少的细胞能量供应。这表明，无法根据可用资源调整能量消耗可能是导致持续性疲劳的一种机制。
Chronic or persistent fatigue is a common, debilitating symptom of several diseases. Persistent fatigue has been associated with low-grade inflammation in several models of fatigue, including cancer-related fatigue and chronic fatigue syndrome. However, it is unclear how low-grade inflammation leads to the experience of fatigue. We here propose a model of an imbalance in energy availability and energy expenditure as a consequence of low-grade inflammation. In this narrative review, we discuss how chronic low-grade inflammation can lead to reduced cellular-energy availability. Low-grade inflammation induces a metabolic switch from energy-efficient oxidative phosphorylation to fast-acting, but less efficient, aerobic glycolytic energy production; increases reactive oxygen species; and reduces insulin sensitivity. These effects result in reduced glucose availability and, thereby, reduced cellular energy. In addition, emerging evidence suggests that chronic low-grade inflammation is associated with increased willingness to exert effort under specific circumstances. Circadian-rhythm changes and sleep disturbances might mediate the effects of inflammation on cellular-energy availability and non-adaptive energy expenditure. In the second part of the review, we present evidence for these metabolic pathways in models of persistent fatigue, focusing on chronic fatigue syndrome and cancer-related fatigue. Most evidence for reduced cellular-energy availability in relation to fatigue comes from studies on chronic fatigue syndrome. While the mechanistic evidence from the cancer-related fatigue literature is still limited, the sparse results point to reduced cellular-energy availability as well. There is also mounting evidence that behavioral-energy expenditure exceeds the reduced cellular-energy availability in patients with persistent fatigue. This suggests that an inability to adjust energy expenditure to available resources might be one mechanism underlying persistent fatigue.
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影响因子：
5.2
作者：
Blázquez E;Velázquez E;Hurtado-Carneiro V;Ruiz-Albusac JM
通讯作者：
Ruiz-Albusac JM
影响因子：
25.7
作者：
Dumas, Jean-Francois;Goupille, Caroline;Couet, Charles
通讯作者：
Couet, Charles
影响因子：
5.6
作者：
Caron, Aimee M.;Stephenson, Richard
通讯作者：
Stephenson, Richard
影响因子：
3.3
作者：
Anderson, Sean T.;O'Callaghan, Emma K.;Coogan, Andrew N.
通讯作者：
Coogan, Andrew N.
DOI：
10.1038/npp.2017.231
发表时间：
2018-04
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
Draper A;Koch RM;van der Meer JW;Aj Apps M;Pickkers P;Husain M;van der Schaaf ME
通讯作者：
van der Schaaf ME