Mobile phone signal exposure triggers a hormesis-like effect in Atm(+/+) and Atm(-/-) mouse embryonic fibroblasts.
Mobile phone signal exposure triggers a hormesis-like effect in Atm(+/+) and Atm(-/-) mouse embryonic fibroblasts.
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手机信号暴露会在 Atm / 和 Atm-/- 小鼠胚胎成纤维细胞中触发类似毒物兴奋效应的效应。
DOI：
10.1038/srep37423
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发表时间：
2016-11-18
影响因子：
4.6
通讯作者：
Xu Z
中科院分区：
文献类型：
--
作者：
Sun C;Wei X;Fei Y;Su L;Zhao X;Chen G;Xu Z
射频电磁场（rf - emf）已被国际癌症研究机构列为可能对人类致癌的物质；然而，这一结论是基于有限的流行病学发现，缺乏实验研究的坚实支持。特别是，关于rf - emf的遗传毒性没有一致的数据。共济失调毛细血管扩张突变（ATM）被认为是基因组稳定性的主要监护人。为了解决关于RF-EMF是否具有遗传毒性的争论，我们比较了1800 MHz RF-EMF暴露对小鼠胚胎成纤维细胞（mef）中精通（Atm+/+）或缺乏（Atm - / -） Atm的基因组DNA的影响。在Atm+/+ mef中，平均特殊吸收率为4.0 W/kg的RF-EMF暴露1小时可诱导显著的DNA单链断裂（SSB）并激活SSB修复机制。在暴露36小时后，这种影响将DNA损伤降低到低于背景水平。在Atm - / - mef中，相同的RF-EMF暴露12小时诱导了SSBs和双链断裂，并激活了两种修复过程，在长时间暴露后，DNA损伤也减少到低于对照水平。所观察到的现象类似于有毒物质在低剂量下的激效。据我们所知，这项研究是第一个报道射频电磁场类似激效效应的研究。
Radiofrequency electromagnetic fields (RF-EMFs) have been classified by the International Agency for Research on Cancer as possible carcinogens to humans; however, this conclusion is based on limited epidemiological findings and lacks solid support from experimental studies. In particular, there are no consistent data regarding the genotoxicity of RF-EMFs. Ataxia telangiectasia mutated (ATM) is recognised as a chief guardian of genomic stability. To address the debate on whether RF-EMFs are genotoxic, we compared the effects of 1,800 MHz RF-EMF exposure on genomic DNA in mouse embryonic fibroblasts (MEFs) with proficient (Atm+/+) or deficient (Atm−/−) ATM. In Atm+/+ MEFs, RF-EMF exposure for 1 h at an average special absorption rate of 4.0 W/kg induced significant DNA single-strand breaks (SSBs) and activated the SSB repair mechanism. This effect reduced the DNA damage to less than that of the background level after 36 hours of exposure. In the Atm−/− MEFs, the same RF-EMF exposure for 12 h induced both SSBs and double-strand breaks and activated the two repair processes, which also reduced the DNA damage to less than the control level after prolonged exposure. The observed phenomenon is similar to the hormesis of a toxic substance at a low dose. To the best of our knowledge, this study is the first to report a hormesis-like effect of an RF-EMF.
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影响因子：
2.2
作者：
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通讯作者：
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通讯作者：
Lindholm C
影响因子：
11.4
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Costanzo, Vincenzo