MRI-based Medical Nanorobotic Platform for the Control of Magnetic Nanoparticles and Flagellated Bacteria for Target Interventions in Human Capillaries.
MRI-based Medical Nanorobotic Platform for the Control of Magnetic Nanoparticles and Flagellated Bacteria for Target Interventions in Human Capillaries.
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DOI：
10.1177/0278364908104855
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发表时间：
2009-09-01
期刊：
影响因子：
--
通讯作者：
Tabatabaei N
中科院分区：
文献类型：
--
作者：
Martel S;Felfoul O;Mathieu JB;Chanu A;Tamaz S;Mohammadi M;Mankiewicz M;Tabatabaei N
医疗纳米机器人利用机器人的纳米级部件和现象来提供新的医疗诊断和干预工具。本文描述了一种基于纳米机器人和纳米医学的、适用于无法插管的靶区的新型医学介入平台的结构和主要技术指标。该机器人平台使用磁共振成像(MRI)来将信息反馈给控制器，该控制器负责沿着非拴系磁性载体、纳米机器人和/或趋磁细菌(MTB)的血管中的预先规划的路径进行实时控制和导航，MTB装载有类似于无线机械臂、机械手或执行特定远程任务所需的其他延伸物的感官或治疗剂。与已知的磁靶向方法不同，本平台允许我们到达人体深处的位置，同时使用实时导航或轨迹控制来增强靶向效率。这篇论文描述了该平台的几个版本，通过额外的软件和硬件模块升级，允许增强靶向效率，并在非常困难的位置进行手术，例如只能通过复杂的微血管网络进入的肿瘤病变。
Medical nanorobotics exploits nanometer-scale components and phenomena with robotics to provide new medical diagnostic and interventional tools. Here, the architecture and main specifications of a novel medical interventional platform based on nanorobotics and nanomedicine, and suited to target regions inaccessible to catheterization are described. The robotic platform uses magnetic resonance imaging (MRI) for feeding back information to a controller responsible for the real-time control and navigation along pre-planned paths in the blood vessels of untethered magnetic carriers, nanorobots, and/or magnetotactic bacteria (MTB) loaded with sensory or therapeutic agents acting like a wireless robotic arm, manipulator, or other extensions necessary to perform specific remote tasks. Unlike known magnetic targeting methods, the present platform allows us to reach locations deep in the human body while enhancing targeting efficacy using real-time navigational or trajectory control. The paper describes several versions of the platform upgraded through additional software and hardware modules allowing enhanced targeting efficacy and operations in very difficult locations such as tumoral lesions only accessible through complex microvasculature networks.
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