Carbohydrate-deficient transferrin in serum in patients with liver diseases.
Carbohydrate-deficient transferrin in serum in patients with liver diseases.
复制标题
肝病患者血清中碳水化合物缺乏的转铁蛋白。
DOI：
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Rolf Hultcrantz
中科院分区：
文献类型：
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作者：
Helena Stibler;Rolf Hultcrantz
通过 pH 5.65 的等度微阴离子交换色谱法分析血清中缺乏碳水化合物的转铁蛋白 (CDT)，然后对 102 名经活检证实患有肝病的患者进行转铁蛋白放射免疫测定。无论肝病类型或程度如何，87 名非酗酒患者的 CDT 值均正常。目前正在滥用药物的 15 名酗酒者中，有 13 名 (87%) 的 CDT 值升高，而在戒酒且仍有肝病的患者中，CDT 值正常。未发现 CDT 水平与肝纤维化或脂肪变性的体积密度或许多临床化学肝脏测试值之间存在相关性。所证明的唯一显着相关性是 CDT 浓度与酗酒患者当前每日饮酒量之间的相关性。这些结果表明，即使在患有各种肝脏疾病的患者中，CDT 也可以用作当前而非先前酗酒的标志。
Carbohydrate-deficient transferrin (CDT) in serum was analyzed by isocratic microanion exchange chromatography at pH 5.65 followed by a transferrin radioimmunoassay in 102 patients with biopsy-verified liver diseases. CDT values were normal in all of the 87 nonalcohol-abusing patients irrespective of type or degree of liver disease. Thirteen of the 15 alcoholic patients (87%) with current abuse showed elevated CDT values while in abstaining alcoholics with remaining liver disease the values were normal. No correlations were found between CDT level and volume density of liver fibrosis or steatosis or values of a number of clinicochemical liver tests. The only significant correlation demonstrated was between CDT concentration and the level of present daily alcohol consumption in the alcoholic patients. These results indicate that CDT can be used as a marker of present but not previous alcohol abuse, even in patients with various liver diseases.
在乙醇存在下培养的粘膜细胞合成和分泌胃粘液糖蛋白。
影响因子：
3.9
作者：
Slomiany,A;Takagi,A;Slomiany,BL
通讯作者：
Slomiany,BL
急性乙醇给药后肝脏质膜糖蛋白组装受损。
DOI：
10.1016/s0006-291x(84)80226-0
发表时间：
1984
影响因子：
3.1
作者：
Mailliard,ME;Sorrell,MF;Volentine,GD;Tuma,DJ
通讯作者：
Tuma,DJ