Cognitive functioning in men receiving androgen deprivation therapy for prostate cancer: a systematic review and meta-analysis.
Cognitive functioning in men receiving androgen deprivation therapy for prostate cancer: a systematic review and meta-analysis.
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DOI：
10.1007/s00520-014-2285-1
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发表时间：
2014-08
影响因子：
3.1
通讯作者：
Jacobsen, Paul B.
中科院分区：
文献类型：
--
作者：
McGinty, Heather L.;Phillips, Kristin M.;Jim, Heather S. L.;Cessna, Julie M.;Asvat, Yasmin;Cases, Mallory G.;Small, Brent J.;Jacobsen, Paul B.
关键词：
先前的研究检查了雄激素剥夺疗法（ADT）对前列腺癌认知表现的影响，发现了不一致的关系。本研究的目的是系统地回顾现有文献，并利用元分析确定ADT对七个认知领域的表现的影响。通过对PubMed Medline、PsycINFO、Cochrane Library和Web of Knowledge/Science数据库的搜索，我们得到了157篇由独立评价者评审的独特摘要。荟萃分析包括14项研究，共417例接受ADT治疗的患者。客观神经心理测试分为七个认知领域：注意/工作记忆、执行功能、语言、言语记忆、视觉记忆、视觉运动能力和视觉空间能力。通过将接受ADT的患者与1)前列腺癌患者对照，2)非癌症对照，或3)ADT患者自己的ADT前基线进行两两比较，计算每个认知领域的单独效应量。接受ADT治疗的患者在视觉运动任务上的表现不如对照组或他们自己的基线（g= - 0.67, p= 0.008; n=193）。在随访时间较短的研究中，缺陷的幅度更大（p= 0.04）。其他六个认知领域没有观察到显著的效应量（p=.08= -.98）。与非癌症对照组相比，接受ADT治疗的前列腺癌患者在视觉运动任务上的表现明显更差。这些发现与睾酮对健康男性认知功能的已知影响是一致的。了解ADT的认知效应可以帮助患者和医疗服务提供者更好地了解ADT对生活质量的影响。
Prior research examining the impact of androgen deprivation therapy (ADT) for prostate cancer on cognitive performance has found inconsistent relationships. The purpose of this study was to systematically review the existing literature and determine the effect of ADT on performance across seven cognitive domains using meta-analysis. A search of PubMed Medline, PsycINFO, Cochrane Library, and Web of Knowledge/Science databases yielded 157 unique abstracts reviewed by independent pairs of raters. Fourteen studies with a total of 417 patients treated with ADT were included in the meta-analysis. Objective neuropsychological tests were categorized into seven cognitive domains: attention/working memory, executive functioning, language, verbal memory, visual memory, visuomotor ability, and visuospatial ability. Separate effect sizes were calculated for each cognitive domain using pairwise comparisons of patients who received ADT with 1) prostate cancer patient controls, 2) non-cancer controls, or 3) ADT patients’ own pre-ADT baselines. Patients treated with ADT performed worse than controls or their own baseline on visuomotor tasks (g=−0.67, p=.008; n=193). The magnitude of the deficits was larger in studies with a shorter time to follow-up (p=.04). No significant effect sizes were observed for the other six cognitive domains (p=.08=–.98). Prostate cancer patients who received ADT performed significantly worse on visuomotor tasks compared to non-cancer control groups. These findings are consistent with the known effects of testosterone on cognitive functioning in healthy men. Knowledge of the cognitive effects of ADT may help patients and providers better understand the impact of ADT on quality of life.
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影响因子：
3.8
作者：
Cherrier MM;Borghesani PR;Shelton AL;Higano CS
通讯作者：
Higano CS
DOI：
10.1136/bmj.b2535
发表时间：
2009-07-21
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Moher D;Liberati A;Tetzlaff J;Altman DG;PRISMA Group
通讯作者：
PRISMA Group
影响因子：
4.5
作者：
Jenkins, VA;Bloomfield, DJ;Edginton, TL
通讯作者：
Edginton, TL
影响因子：
6.2
作者：
Jansen, CE;Miaskowski, C;Kramer, J
通讯作者：
Kramer, J
影响因子：
4.6
作者：
LINN, MC;PETERSEN, AC
通讯作者：
PETERSEN, AC