Peripheral sTREM2-Related Inflammatory Activity Alterations in Early-Stage Alzheimer's Disease.
Peripheral sTREM2-Related Inflammatory Activity Alterations in Early-Stage Alzheimer's Disease.
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早期阿尔茨海默病中外周strem - 2相关炎症活性改变
DOI：
10.4049/jimmunol.2100771
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发表时间：
2022-05-15
期刊：
影响因子：
--
通讯作者：
Bekris LM
中科院分区：
文献类型：
--
作者：
Weber GE;Khrestian M;Tuason ED;Shao Y;Pillai J;Rao S;Feng H;Zhou Y;Cheng F;DeSilva TM;Stauffer S;Leverenz JB;Bekris LM
Alzheimer’s disease (AD) has been linked to multiple immune system related genetic variants. Triggering receptor expressed on myeloid cells 2 (TREM2) genetic variants are risk factors for AD and other neurodegenerative diseases. In addition, soluble TREM2 isoform (sTREM2) is elevated in cerebrospinal fluid in the early stages of AD and associated with slower cognitive decline in a disease stage dependent manner. Multiple studies have reported an altered peripheral immune response in AD. However, less is known about the relationship between peripheral sTREM2 and an altered peripheral immune response in AD. The objective of this study was to explore the relationship between human plasma sTREM2 and inflammatory activity in AD. The hypothesis of this exploratory study was that sTREM2 related inflammatory activity differs by AD stage. We observed different patterns of inflammatory activity across AD stages that implicates early stage alterations in peripheral sTREM2-related inflammatory activity in AD. Notably, fractalkine showed a significant relationship with sTREM2 across different analyses in the control groups that was lost in later AD-related stages with high levels in the MCI. Although, multiple other inflammatory factors either differed significantly between groups or were significantly correlated with sTREM2 within specific groups, three inflammatory factors (FGF-2, GM-CSF and IL-1β) are notable since they exhibited both lower levels in AD, compared to MCI, and a change in the relationship with sTREM2. This evidence provides important support to the hypothesis that sTREM2-related inflammatory activity alterations are AD stage specific and provides critical information for therapeutic strategies focused the immune response.
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影响因子：
4.3
作者：
Deleidi M;Jäggle M;Rubino G
通讯作者：
Rubino G
DOI：
10.1056/nejmoa1211851
发表时间：
2013-01-10
期刊：
The New England journal of medicine
影响因子：
--
作者：
Guerreiro R;Wojtas A;Bras J;Carrasquillo M;Rogaeva E;Majounie E;Cruchaga C;Sassi C;Kauwe JS;Younkin S;Hazrati L;Collinge J;Pocock J;Lashley T;Williams J;Lambert JC;Amouyel P;Goate A;Rademakers R;Morgan K;Powell J;St George-Hyslop P;Singleton A;Hardy J;Alzheimer Genetic Analysis Group
通讯作者：
Alzheimer Genetic Analysis Group
影响因子：
3.3
作者：
Bekris LM;Khrestian M;Dyne E;Shao Y;Pillai JA;Rao SM;Bemiller SM;Lamb B;Fernandez HH;Leverenz JB
通讯作者：
Leverenz JB
影响因子：
15.1
作者：
Franzmeier N;Suárez-Calvet M;Frontzkowski L;Moore A;Hohman TJ;Morenas-Rodriguez E;Nuscher B;Shaw L;Trojanowski JQ;Dichgans M;Kleinberger G;Haass C;Ewers M;Alzheimer’s Disease Neuroimaging Initiative (ADNI)
通讯作者：
Alzheimer’s Disease Neuroimaging Initiative (ADNI)
影响因子：
7.3
作者：
Chen X;Hu Y;Cao Z;Liu Q;Cheng Y
通讯作者：
Cheng Y