Coping strategies in patients with acute myeloid leukemia.
Coping strategies in patients with acute myeloid leukemia.
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DOI：
10.1182/bloodadvances.2021005845
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发表时间：
2022-04-12
期刊：
影响因子：
7.5
通讯作者：
El-Jawahri, Areej
中科院分区：
文献类型：
--
作者：
Amonoo, Hermioni L.;Bodd, Monica H.;Reynolds, Matthew J.;Nelson, Ashley M.;Newcomb, Richard;Johnson, Patrick Connor;Dhawale, Tejaswini M.;Plotke, Rachel;Heuer, Lauren;Gillani, Sabah;Yang, Daniel;Deary, Emma C.;Daskalakis, Elizabeth;Goldschen, Lauren;Brunner, Andrew;Fathi, Amir T.;LeBlanc, Thomas W.;El-Jawahri, Areej
新诊断为高风险AML的患者被迫科普密集的毒性治疗。使用以接近为导向的应对策略与较少的心理困扰和更好的生活质量相关。诊断为急性髓细胞白血病（AML）的患者面临着突然发作的危及生命的疾病，需要强化治疗。虽然他们的早期疾病轨迹的特点是显着的，毒副作用，有限的数据描述了AML患者的应对策略，以及这些如何告知患者报告的结果。我们使用横断面二级数据分析来描述160例新诊断的高危AML患者的应对方式。在AML诊断时，使用简明科普、医院焦虑和抑郁量表、创伤后应激障碍检查表-平民版和癌症治疗功能评估-白血病分别测量应对策略、心理困扰和生活质量（QOL）。应对领域分布的中位数分裂法和多变量回归模型被用来评估应对和患者报告的结果之间的关系。参与者（中位年龄64.4岁）大多为非西班牙裔白色（86.3%）、男性（60.0%）和已婚（73.8%）。大多数（51.9%）的被试对接近型应对策略的使用率较高，而对回避型应对策略的使用率较高的被试占38.8%。在诊断时，使用以接近为导向的应对方式与较少的心理困扰（焦虑，β =-0.262，P = .002;抑郁症状，β =-0.311，P < .001;创伤后抑郁障碍症状，β =-0.596，P = .006）和较好的生活质量（β = 1.491，P = .003）相关。使用回避型应对与更多的心理困扰（焦虑，β = 0.884，P < .001;抑郁症状，β = 0.697，P < .001;创伤后抑郁障碍症状，β = 3.048，P < .001）和更差的生活质量（β =-5.696，P < .001）相关。高风险AML患者在诊断时使用各种以接近为导向的和回避的应对策略。使用以方法为导向的应对策略与较少的心理困扰和更好的生活质量相关，这表明支持性肿瘤干预可能的目标。
Patients newly diagnosed with high-risk AML are forced to cope with intensive, toxic treatments. Use of approach-oriented coping strategies was associated with less psychological distress and better QOL. Patients diagnosed with acute myeloid leukemia (AML) face sudden-onset life-threatening disease that requires intensive treatments. Although their early disease trajectory is characterized by significant, toxic side effects, limited data are available describing coping strategies among patients with AML and how these inform patient-reported outcomes. We used cross-sectional secondary data analyses to describe coping in 160 patients with newly diagnosed high-risk AML. The Brief COPE, Hospital Anxiety and Depression Scale, Post-Traumatic Stress Disorder Checklist–Civilian Version, and Functional Assessment of Cancer Therapy–Leukemia were used at time of AML diagnosis to measure coping strategies, psychological distress, and quality of life (QOL), respectively. The median split method for distribution of coping domains and multivariate regression models were used to assess the relationship between coping and patient-reported outcomes. Participants (median age, 64.4 years) were mostly non-Hispanic White (86.3%), male (60.0%), and married (73.8%). Most (51.9%) had high utilization of approach-oriented coping strategies, whereas 38.8% had high utilization of avoidant coping strategies. At time of diagnosis, use of approach-oriented coping was associated with less psychological distress (anxiety, β = –0.262, P = .002; depression symptoms, β = –0.311, P < .001; and posttraumatic distress disorder symptoms, β = –0.596, P = .006) and better QOL (β = 1.491, P = .003). Use of avoidant coping was associated with more psychological distress (anxiety, β = 0.884, P < .001; depression symptoms, β = 0.697, P < .001; and posttraumatic distress disorder symptoms, β = 3.048, P < .001) and worse QOL (β = –5.696, P < .001). Patients with high-risk AML use various approach-oriented and avoidant coping strategies at time of diagnosis. Use of approach-oriented coping strategies was associated with less psychological distress and better QOL, suggesting a possible target for supportive oncology interventions.
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影响因子：
6.2
作者：
Nipp, Ryan D.;El-Jawahri, Areej;Fishbein, Joel N.;Eusebio, Justin;Stagl, Jamie M.;Gallagher, Emily R.;Park, Elyse R.;Jackson, Vicki A.;Pirl, William F.;Greer, Joseph A.;Temel, Jennifer S.
通讯作者：
Temel, Jennifer S.
影响因子：
120.7
作者：
Phelps, Andrea C.;Maciejewski, Paul K.;Prigerson, Holly G.
通讯作者：
Prigerson, Holly G.
影响因子：
2.7
作者：
Nissim, Rinat;Zimmermann, Camilla;Rodin, Gary
通讯作者：
Rodin, Gary
影响因子：
3.6
作者：
Costanzo, ES;Lutgendorf, SK;Anderson, B
通讯作者：
Anderson, B
影响因子：
7.6
作者：
CARVER, CS;SCHEIER, MF;WEINTRAUB, JK
通讯作者：
WEINTRAUB, JK