Medial amygdala ERα expression influences monogamous behaviour of male prairie voles in the field.
Medial amygdala ERα expression influences monogamous behaviour of male prairie voles in the field.
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DOI：
10.1098/rspb.2021.0318
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发表时间：
2021-08-11
期刊：
影响因子：
--
通讯作者：
Solomon NG
中科院分区：
文献类型：
--
作者：
Lambert CT;Lichter JB;Perry AN;Castillo SA;Keane B;Cushing BS;Solomon NG
长期配对键的形成是一个复杂的过程，涉及多个神经回路，并且依赖于上下文和经验。虽然使用草原田鼠的实验室研究已经确定了几种神经机制的参与，但将这些发现转化为可预测的实地结果的努力充其量是不一致的。在这里，我们测试的假设，抑制雌激素受体α（ERα）在内侧杏仁核的雄性草原田鼠将显着增加社会一夫一妻制在外地的表达。在室外围栏中建立了等性比的草原田鼠种群，雄性繁殖高水平的ERα表达和低水平的与社会一夫一妻制相关的亲社会行为。每个群体中有一半男性的内侧杏仁核ERα表达被敲低。击倒男性表现出更大程度的社会一夫一妻制的八个行为指数评估的五个。这项研究表明，ERα在男性社会一夫一妻制的表达中发挥着关键作用。
Formation of long-term pair-bonds is a complex process, involving multiple neural circuits and is context- and experience-dependent. While laboratory studies using prairie voles have identified the involvement of several neural mechanisms, efforts to translate these findings into predictable field outcomes have been inconsistent at best. Here we test the hypothesis that inhibition of oestrogen receptor alpha (ERα) in the medial amygdala of male prairie voles would significantly increase the expression of social monogamy in the field. Prairie vole populations of equal sex ratio were established in outdoor enclosures with males bred for high levels of ERα expression and low levels of prosocial behaviour associated with social monogamy. Medial amygdala ERα expression was knocked down in half the males per population. Knockdown males displayed a greater degree of social monogamy in five of the eight behavioural indices assessed. This study demonstrates the robust nature of ERα in playing a critical role in the expression of male social monogamy in a field setting.
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影响因子：
2.5
作者：
Hammock, EAD;Lim, MM;Young, LJ
通讯作者：
Young, LJ
影响因子：
2.4
作者：
Garamszegi, Laszlo Zsolt
通讯作者：
Garamszegi, Laszlo Zsolt
DOI：
10.1073/pnas.92.17.7744
发表时间：
1995-08-15
影响因子：
11.1
作者：
DEVRIES, AC;DEVRIES, MB;CARTER, CS
通讯作者：
CARTER, CS
影响因子：
5.3
作者：
Aragona, BJ;Liu, Y;Wang, ZX
通讯作者：
Wang, ZX
影响因子：
2.5
作者：
CAIRNS, SJ;SCHWAGER, SJ
通讯作者：
SCHWAGER, SJ