Nonlinearity of intracochlear motion and local cochlear microphonic: Comparison between guinea pig and gerbil.
Nonlinearity of intracochlear motion and local cochlear microphonic: Comparison between guinea pig and gerbil.
复制标题
豚鼠和沙土鼠耳内运动和局部耳蜗微音响的非线性比较。
DOI：
10.1016/j.heares.2021.108234
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发表时间：
2021-06
期刊：
影响因子：
2.8
通讯作者：
Olson ES
中科院分区：
文献类型：
--
作者：
Fallah E;Strimbu CE;Olson ES
研究几个物种的耳蜗在体机械和电生理反应有助于我们全面了解耳蜗的灵敏度和频率选择性。不同的物种可能使用不同的机制来实现清晰的频率-位置图。外毛细胞（OHC）在介导频率调谐中起着重要作用。在本工作中，我们测量了OHC产生的局部耳蜗颤噪（LCM）和不同层次的Corti器官中的运动，使用光学相干断层扫描（OCT）在第一轮的豚鼠耳蜗。在最佳频率（BF）波段，我们的观察结果与我们以前在沙鼠中的测量结果相似：LCM响应和基底膜（BM）和OHC区域位移的非线性峰值，以及OHC区域比BM更高的运动。亚BF两个物种的反应是不同的。在这两个物种的亚BF位移的BM是线性和LCM是非线性的。在OHC区域的子BF中，仅在健康豚鼠耳蜗的一个子集中观察到非线性，而在沙鼠中，在所有健康耳蜗中观察到稳健的非线性。这些差异表明，沙鼠和豚鼠采用不同的机制，从BM反应中过滤亚BF OHC活性。然而，不能排除这些差异是由于物种之间的技术测量差异造成的。
Studying the in-vivo mechanical and electrophysiological cochlear responses in several species helps us to have a comprehensive view of the sensitivity and frequency selectivity of the cochlea. Different species might use different mechanisms to achieve the sharp frequency-place map. The outer hair cells (OHC) play an important role in mediating frequency tuning. In the present work, we measured the OHC-generated local cochlear microphonic (LCM) and the motion of different layers in the organ of Corti using optical coherence tomography (OCT) in the first turn of the cochlea in guinea pig. In the best frequency (BF) band, our observations were similar to our previous measurements in gerbil: a nonlinear peak in LCM responses and in the basilar membrane (BM) and OHC-region displacements, and higher motion in the OHC region than the BM. Sub-BF the responses in the two species were different. In both species the sub-BF displacement of the BM was linear and LCM was nonlinear. Sub-BF in the OHC-region, nonlinearity was only observed in a subset of healthy guinea pig cochleae while in gerbil, robust nonlinearity was observed in all healthy cochleae. The differences suggest that gerbils and guinea pigs employ different mechanisms for filtering sub-BF OHC activity from BM responses. However, it cannot be ruled out that the differences are due to technical measurement differences across the species.
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影响因子：
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通讯作者：
Nuttall, Alfred L.