Susceptibility weighted imaging of cartilage canals in porcine epiphyseal growth cartilage ex vivo and in vivo.
Susceptibility weighted imaging of cartilage canals in porcine epiphyseal growth cartilage ex vivo and in vivo.
复制标题
DOI：
10.1002/mrm.24863
复制
发表时间：
2014-06
影响因子：
3.3
通讯作者：
Ellermann, Jutta M.
中科院分区：
文献类型：
--
作者：
Nissi, Mikko J.;Toth, Ferenc;Zhang, Jinjin;Schmitter, Sebastian;Benson, Michael;Carlson, Cathy S.;Ellermann, Jutta M.
软骨管的高分辨率可视化仅限于组织学方法和对比增强成像。在这项研究中，非对比增强磁敏感加权成像（SWI）的可行性进行了研究，离体在9.4 T，进一步探讨在7和3 T，并证明在体内在7 T，使用猪动物模型的软骨管可视化。采用3D-GRE序列和SWI后处理技术，在9.4T下对1 ~ 8周龄仔猪股骨远端和肱骨标本进行SWI扫描。在7 T和3 T下对2周龄仔猪的后膝关节进行离体扫描。最后，使用供应商提供的序列，在全身麻醉下以7 T对3周龄小猪的相同部位进行体内扫描。高对比度可视化的软骨管获得离体，特别是在较高的场强，结果证实了组织学。在7 T下证明了体内可行性，在3 T和7 T下的离体扫描比较表明在3 T下使用SWI的可行性。使用SWI展示了软骨管的高分辨率3D可视化。这种完全无创可视化的演示为探索骨骼成熟和血管供应在骨软骨病等疾病中的作用开辟了新的途径。
High-resolution visualization of cartilage canals has been restricted to histological methods and contrast-enhanced imaging. In this study, the feasibility of non-contrast-enhanced susceptibility weighted imaging (SWI) for visualization of the cartilage canals was investigated ex vivo at 9.4 T, further explored at 7 and 3 T and demonstrated in vivo at 7 T, using a porcine animal model. SWI scans of specimens of distal femur and humerus from 1 to 8 week-old piglets were conducted at 9.4 T using 3D-GRE sequence and SWI post-processing. The stifle joints of a 2-week old piglet were scanned ex vivo at 7 and 3 T. Finally, the same sites of a 3-week-old piglet were scanned, in vivo, at 7 T under general anesthesia using the vendor-provided sequences. High-contrast visualization of the cartilage canals was obtained ex vivo, especially at higher field strengths; the results were confirmed histologically. In vivo feasibility was demonstrated at 7 T and comparison of ex vivo scans at 3 and 7 T indicated feasibility of using SWI at 3 T. High-resolution 3D visualization of cartilage canals was demonstrated using SWI. This demonstration of fully noninvasive visualization opens new avenues to explore skeletal maturation and the role of vascular supply for diseases such as osteochondrosis.
登录
查看更多内容
影响因子：
4.4
作者：
Haacke, E. M.;Tang, J.;Neelavalli, J.;Cheng, Y. C. N.
通讯作者：
Cheng, Y. C. N.
影响因子：
3.3
作者：
Dixon, Jennifer Elizabeth;Simpson, Ashley;Morris, Peter Gordon
通讯作者：
Morris, Peter Gordon
人脑高场MRI的敏感性对比与组织铁含量的关系。
影响因子：
5.7
作者：
Yao B;Li TQ;Gelderen Pv;Shmueli K;de Zwart JA;Duyn JH
通讯作者：
Duyn JH
影响因子：
4.8
作者：
Abosch, Aviva;Yacoub, Essa;Harel, Noam
通讯作者：
Harel, Noam
影响因子：
2.5
作者：
Wang, Meiyun;Dai, Yongming;Shi, Dapeng
通讯作者：
Shi, Dapeng