Natural product leads for drug discovery: isolation, synthesis and biological evaluation of 6-cyano-5-methoxyindolo[2,3-a]carbazole based ligands as antibacterial agents.
Natural product leads for drug discovery: isolation, synthesis and biological evaluation of 6-cyano-5-methoxyindolo[2,3-a]carbazole based ligands as antibacterial agents.
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DOI：
10.1016/j.bmc.2009.08.061
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发表时间：
2009-10-15
影响因子：
3.5
通讯作者：
Kozikowski, Alan P.
中科院分区：
文献类型：
--
作者：
Guo, Songpo;Tipparaju, Suresh K.;Pegan, Scott D.;Wan, Baojie;Moa, Shunyan;Orjala, Jimmy;Mesecar, Andrew D.;Franzblau, Scott G.;Kozikowski, Alan P.
以靛蓝为原料，经七步线性合成路线合成了吲哚并[2，3-a]咔唑类缓蚀剂，总收率适中。抑制剂选择性地和容易地在咔唑单元的吲哚部分上的氮官能化。合成的类似物对B具有中等的抑制活性。anthracis和M.结核病，表明吲哚[2，3-a]咔唑可以作为有希望的领导，在新的药物开发，以打击炭疽和结核病感染。
Indolo[2,3-a]carbazole based inhibitors were synthesized from readily available indigo via a seven-step linear synthetic sequence with a moderate overall yield. The inhibitors were selectively and readily functionalized at the nitrogen on the indole portion of the carbazole unit. The synthesized analogs displayed moderate inhibitory activities toward B. anthracis and M. tuberculosis, indicating that indolo[2,3-a]carbazoles could serve as promising leads in the development of new drugs to combat anthrax and tuberculosis infections.
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影响因子：
18.3
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MICHEL, RH
影响因子：
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BRADNER, WT
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通讯作者：
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