The CAR T-Cell Mechanoimmunology at a Glance.
The CAR T-Cell Mechanoimmunology at a Glance.
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一眼的汽车T细胞机械免疫学。
DOI：
10.1002/advs.202002628
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发表时间：
2020-12
期刊：
影响因子：
--
通讯作者：
Chen W
中科院分区：
文献类型：
--
作者：
Li R;Ma C;Cai H;Chen W
嵌合抗原受体(CAR)T细胞转移是过继T细胞免疫治疗的一种新范式。当与靶癌细胞接触时，CAR T细胞与癌细胞形成非经典的免疫突触，并动态地协调多种关键力量来承担细胞毒免疫功能。这种免疫过程涉及CAR的力传递和细胞骨架的时空重塑，以促进CAR的激活和CAR T细胞的细胞毒功能。然而，对于CAR T细胞和靶细胞之间的这种机械转导的详细了解，以及它的分子结构和信号，仍然不太清楚，而且才刚刚开始出现。本文综述了CAR-T细胞机械免疫学的基本机制和原理，以及从对正常细胞毒性T细胞免疫突触的机械转导的研究中可以比较学到的各种教训。本文还讨论了CAR T细胞机械免疫学研究中生物工程新工具的最新发展和应用前景。相信这份进展报告将阐明CAR T细胞机械免疫学，并鼓励未来的研究，揭示CAR T细胞免疫肿瘤学中涉及的较少探索但重要的机械传感和机械转导机制。这篇进展报告总结了嵌合抗原受体(CAR)T细胞如何通过T细胞和靶癌细胞之间形成的免疫突触协调多种机械力，从而在免疫治疗中成功地发挥细胞毒免疫功能。从机械免疫学的角度对CAR T细胞机械免疫学的理解将有助于未来设计安全而有效的CAR T细胞和机械医学。
Chimeric antigen receptor (CAR) T‐cell transfer is a novel paradigm of adoptive T‐cell immunotherapy. When coming into contact with a target cancer cell, CAR T‐cell forms a nonclassical immunological synapse with the cancer cell and dynamically orchestrates multiple critical forces to commit cytotoxic immune function. Such an immunologic process involves a force transmission in the CAR and a spatiotemporal remodeling of cell cytoskeleton to facilitate CAR activation and CAR T‐cell cytotoxic function. Yet, the detailed understanding of such mechanotransduction at the interface between the CAR T‐cell and the target cell, as well as its molecular structure and signaling, remains less defined and is just beginning to emerge. This article summarizes the basic mechanisms and principles of CAR T‐cell mechanoimmunology, and various lessons that can be comparatively learned from interrogation of mechanotransduction at the immunological synapse in normal cytotoxic T‐cell. The recent development and future application of novel bioengineering tools for studying CAR T‐cell mechanoimmunology is also discussed. It is believed that this progress report will shed light on the CAR T‐cell mechanoimmunology and encourage future researches in revealing the less explored yet important mechanosensing and mechanotransductive mechanisms involved in CAR T‐cell immuno‐oncology. This progress report summarizes how chimeric antigen receptor (CAR) T‐cell orchestrates multiple mechanical forces through the immunological synapse formed between the T‐cell and target cancer cell to successfully commit cytotoxic immune function in immunotherapy. An understanding of the CAR T‐cell mechanoimmunology will shed light on the future design of safe yet efficient CAR T‐cells and mechanomedicines from a mechanoimmunological perspective.
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影响因子：
14.8
作者：
Chang ZL;Lorenzini MH;Chen X;Tran U;Bangayan NJ;Chen YY
通讯作者：
Chen YY
影响因子：
2.8
作者：
Brodovitch, Alexandre;Limozin, Laurent;Bongrand, Pierre;Pierres, Anne
通讯作者：
Pierres, Anne
影响因子：
17.1
作者：
Brentjens RJ;Davila ML;Riviere I;Park J;Wang X;Cowell LG;Bartido S;Stefanski J;Taylor C;Olszewska M;Borquez-Ojeda O;Qu J;Wasielewska T;He Q;Bernal Y;Rijo IV;Hedvat C;Kobos R;Curran K;Steinherz P;Jurcic J;Rosenblat T;Maslak P;Frattini M;Sadelain M
通讯作者：
Sadelain M
DOI：
10.1073/pnas.1218640110
发表时间：
2013-04-09
影响因子：
11.1
作者：
Bertrand, Florie;Mueller, Sabina;Valitutti, Salvatore
通讯作者：
Valitutti, Salvatore
影响因子：
46.9
作者：
Cheung AS;Zhang DKY;Koshy ST;Mooney DJ
通讯作者：
Mooney DJ