Homosynaptic plasticity induction causes heterosynaptic changes at the unstimulated neighbors in an induction pattern and location-specific manner.
Homosynaptic plasticity induction causes heterosynaptic changes at the unstimulated neighbors in an induction pattern and location-specific manner.
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DOI：
10.3389/fncel.2023.1253446
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发表时间：
2023
影响因子：
5.3
通讯作者：
Israely, Inbal
中科院分区：
文献类型：
--
作者：
Argunsah, Ali Ozgur;Israely, Inbal
关键词：
树突棘是一种高度动态的结构，其结构和功能的波动取决于多种因素。突触强度的变化并不局限于直接参与特定活动模式的突触。刺激点内和周围未受刺激的相邻脊椎簇也会发生强度变化。通常，当在谷氨酸去化的单个树突棘上诱导可塑性时，相邻的脊椎不会表现出任何显著的结构波动。在这里，使用双光子成像和在海马锥体神经元单个树突棘上的谷氨酸去化，我们表明在未受刺激的相邻棘上发生结构修改，并且是可塑性诱导刺激的时间模式的函数。此外，未受刺激的邻居在局部树突节段内的相对位置与观察到的异突触可塑性的程度相关。这些发现表明，单个脊椎上的自然主义活动模式可以塑造附近突触簇的可塑性，并可能在为进一步修改而启动局部输入方面发挥作用。
Dendritic spines are highly dynamic structures whose structural and functional fluctuations depend on multiple factors. Changes in synaptic strength are not limited to synapses directly involved in specific activity patterns. Unstimulated clusters of neighboring spines in and around the site of stimulation can also undergo alterations in strength. Usually, when plasticity is induced at single dendritic spines with glutamate uncaging, neighboring spines do not show any significant structural fluctuations. Here, using two-photon imaging and glutamate uncaging at single dendritic spines of hippocampal pyramidal neurons, we show that structural modifications at unstimulated neighboring spines occur and are a function of the temporal pattern of the plasticity-inducing stimulus. Further, the relative location of the unstimulated neighbors within the local dendritic segment correlates with the extent of heterosynaptic plasticity that is observed. These findings indicate that naturalistic patterns of activity at single spines can shape plasticity at nearby clusters of synapses, and may play a role in priming local inputs for further modifications.
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影响因子：
64.8
作者：
Attardo A;Fitzgerald JE;Schnitzer MJ
通讯作者：
Schnitzer MJ
影响因子：
16.2
作者：
Bosch M;Castro J;Saneyoshi T;Matsuno H;Sur M;Hayashi Y
通讯作者：
Hayashi Y
DOI：
10.1126/science.1189664
发表时间：
2010-09-24
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Branco T;Clark BA;Häusser M
通讯作者：
Häusser M
影响因子：
5.8
作者：
Hobbiss AF;Ramiro-Cortés Y;Israely I
通讯作者：
Israely I
影响因子：
5.3
作者：
Colgan, Lesley A.;Parra-Bueno, Paula;Yasuda, Ryohei
通讯作者：
Yasuda, Ryohei