Keishibukuryogan (gui-zhi-fu-ling-wan), a Kampo formula, decreases disease activity and soluble vascular adhesion molecule-1 in patients with rheumatoid arthritis.
Keishibukuryogan (gui-zhi-fu-ling-wan), a Kampo formula, decreases disease activity and soluble vascular adhesion molecule-1 in patients with rheumatoid arthritis.
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Kampo公式Keishibukuryogan（Gui-Zhi-Fu-ling-wan）在类风湿关节炎患者中降低了疾病活性和可溶性血管粘附分子-1。
DOI：
10.1093/ecam/nel025
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发表时间：
2006-09
影响因子：
--
通讯作者：
Shimada, Yutaka
中科院分区：
文献类型：
--
作者：
Nozaki, Kazuya;Hikiami, Hiroaki;Goto, Hirozo;Nakagawa, Takako;Shibahara, Naotoshi;Shimada, Yutaka
据报道，类风湿性关节炎（RA）患者因心血管疾病导致的死亡率不断增加。Keishibukuryogan（KBG）是一种传统的中国/日本（汉方）配方，已被用于患有血液停滞的患者，例如血栓性疾病和动脉粥样硬化。本研究的目的是评估KBG对RA患者疾病活动和内皮功能障碍的疗效。入选16例RA患者，除继续使用其他药物外，还给予KBG（每天12 g）12周。RA的疾病活动性通过28个关节的改良疾病活动性评分（DAS 28）来评估。检测血浆粘附分子、可溶性E-选择素（sE-selectin）、可溶性细胞间粘附分子-1（sICAM-1）和可溶性血管细胞粘附分子-1（sVCAM-1）水平。同时检测C反应蛋白（CRP）、炎性细胞因子（IL-1β、IL-6和TNF-α）和脂质过氧化物（LPO）。14名患者完成了研究。RA的病情活动度、压痛关节数、肿胀关节数和DAS 28均显著降低。在粘附分子中，只有sVCAM-1显著降低。LPO也显著降低，而CRP和炎性细胞因子保持不变。这些结果表明，KBG具有不足的抗炎或免疫调节作用，但对RA患者的关节症状和内皮功能障碍的保护作用确实具有有益的效果。
An increasing death rate due to cardiovascular disease in patients with rheumatoid arthritis (RA) has been reported. Keishibukuryogan (KBG) is a traditional Chinese/Japanese (Kampo) formula that has been administered to patients with blood stagnation, e.g. thrombotic disease and atherosclerosis. The objective of this study was to evaluate the efficacy of KBG on disease activity and endothelial dysfunction in RA patients. Sixteen RA patients were enrolled and administered KBG (12 g per day) for 12 weeks in addition to continuing other drugs. The disease activity of RA was assessed by modified disease activity scores for 28 joints (DAS28). Plasma levels of adhesion molecules, soluble E-selectin (sE-selectin), soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) were evaluated. C-reactive protein (CRP), inflammatory cytokines (IL-1β, IL-6 and TNF-α) and lipid peroxide (LPO) were also evaluated. Fourteen patients completed the study. The disease activity of RA, tender joint count, swollen joint count and DAS28 decreased significantly. Among adhesion molecules, only sVCAM-1 decreased significantly. LPO also decreased significantly, whereas CRP and inflammatory cytokines remained unchanged. These results suggest that KBG has insufficient anti-inflammatory or immunomodulating effect but does have a beneficial effect on articular symptoms and a protective effect against endothelial dysfunction in RA patients.
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影响因子：
7.9
作者：
Goto, H;Shimada, Y;Terasawa, K
通讯作者：
Terasawa, K
影响因子：
5.8
作者：
Desideri, G;Marinucci, MC;Ferri, C
通讯作者：
Ferri, C
影响因子：
64.5
作者：
OSBORN, L;HESSION, C;LOBB, R
通讯作者：
LOBB, R
类风湿关节炎中内皮功能障碍，心血管危险因素和动脉粥样硬化的生物标志物。
影响因子：
4.9
作者：
Dessein, Patrick H;Joffe, Barry I;Singh, Sham
通讯作者：
Singh, Sham
影响因子：
27.4
作者：
Edmonds, SE;Winyard, PG;Blake, DR
通讯作者：
Blake, DR